Our Members
Denisa D. Wagner, PhD - Principal Investigator
Dr. Wagner received her Diploma of Biochemistry from the Universite de Geneve, Switzerland and PhD in Biology from the Massachusetts Institute of Technology. She served on the faculty at the University of Rochester, NY and Tufts University School of Medicine before coming to Harvard Medical School in 1994. Dr. Wagner is currently the Edwin Cohn Professor of Pediatrics in the Program for Cellular and Molecular Medicine and the Division of Hematology/Oncology at Boston Children's Hospital.
E-mail: denisa.wagner@childrens.harvard.edu
Dr. Wagner received her Diploma of Biochemistry from the Universite de Geneve, Switzerland and PhD in Biology from the Massachusetts Institute of Technology. She served on the faculty at the University of Rochester, NY and Tufts University School of Medicine before coming to Harvard Medical School in 1994. Dr. Wagner is currently the Edwin Cohn Professor of Pediatrics in the Program for Cellular and Molecular Medicine and the Division of Hematology/Oncology at Boston Children's Hospital.
E-mail: denisa.wagner@childrens.harvard.edu
Kristen Douthit - Program Coordinator, II
E-mail: Kristen.Douthit@childrens.harvard.edu
E-mail: Kristen.Douthit@childrens.harvard.edu
Ernest Dalle, PhD - Postdoctoral Fellow
Started in the Wagner Lab in August 2021
Previous research
Ernest's research interests are mainly in behavioral neuroscience where he uses animal models to study the pathophysiology of psychiatric and neurological diseases such as Parkinson’s disease, Alzheimer’s disease, and Depression. Ernest uses a variety of behavioral techniques to assess the behavior of rodent animals, and stereotaxic surgery to model neurodegenerative diseases.
Previous Placements
University of KwaZulu-Natal, Durban, South Africa - Postdoctoral research fellow.
University of KwaZulu-Natal, Durban, South Africa - BSc, MSc, PhD in Neurophysiology under the supervision of Prof. Musa Mabandla and Prof. William Daniels.
University of KwaZulu-Natal, Durban, South Africa - Part-time lecturer.
E-mail: Ernest.Dalle@childrens.harvard.edu
Started in the Wagner Lab in August 2021
Previous research
Ernest's research interests are mainly in behavioral neuroscience where he uses animal models to study the pathophysiology of psychiatric and neurological diseases such as Parkinson’s disease, Alzheimer’s disease, and Depression. Ernest uses a variety of behavioral techniques to assess the behavior of rodent animals, and stereotaxic surgery to model neurodegenerative diseases.
Previous Placements
University of KwaZulu-Natal, Durban, South Africa - Postdoctoral research fellow.
University of KwaZulu-Natal, Durban, South Africa - BSc, MSc, PhD in Neurophysiology under the supervision of Prof. Musa Mabandla and Prof. William Daniels.
University of KwaZulu-Natal, Durban, South Africa - Part-time lecturer.
E-mail: Ernest.Dalle@childrens.harvard.edu
Lukas Heger, MD/PhD - Postdoctoral Fellow
Started in the Wagner Lab in September 2021
Previous Research
Lukas has worked as a clinical scientist and medical doctor at university hospital Freiburg, Germany since 2016 and was member of the working group „Platelets in Inflammation“ (Prof. D. Dürschmied) from 2016 - 2021 and the working group „Biomarkers in cardiovascular medicine“ (Heger/Hortmann) from 2019 – to date. Lukas´s work has focused on inflammation in myocardial infarction (MI) and reperfusion injury. He investigated the role of Toll-like-receptors (TLR) in platelet signaling and activation during MI. Recently, Lukas investigated complement factor dysregulation in COVID-19 disease. Lukas is funded by the German research foundation (DFG; HE 8679/1-1:1).
Previous Placements
Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Germany - MD
E-mail: lukas.heger@childrens.harvard.edu
Started in the Wagner Lab in September 2021
Previous Research
Lukas has worked as a clinical scientist and medical doctor at university hospital Freiburg, Germany since 2016 and was member of the working group „Platelets in Inflammation“ (Prof. D. Dürschmied) from 2016 - 2021 and the working group „Biomarkers in cardiovascular medicine“ (Heger/Hortmann) from 2019 – to date. Lukas´s work has focused on inflammation in myocardial infarction (MI) and reperfusion injury. He investigated the role of Toll-like-receptors (TLR) in platelet signaling and activation during MI. Recently, Lukas investigated complement factor dysregulation in COVID-19 disease. Lukas is funded by the German research foundation (DFG; HE 8679/1-1:1).
Previous Placements
Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Germany - MD
E-mail: lukas.heger@childrens.harvard.edu
Pierre-André Jarrot, MD/PhD - Postdoctoral Fellow
Started in the Wagner Lab in September 2022
Previous Research
Pierre-André has worked as assistant professor in the department of internal medicine and clinical immunology at university hospital of Marseille (France) since 2016. His research thematic is related to its clinical practice and focused on inflammatory mechanisms in small vessels vasculitis. He performed his PhD in center of cardiovascular and nutrition research (C2VN) in Aix-Marseille University, where he investigated the role of neutrophil extracellular traps in a diffuse intra alveolar hemorrhage murine model, a rare but threatening complication of vasculitis.
Previous placements
Department of Internal Medicine and Clinical Immunology, Conception’s Hospital, APHM, Marseille (France)-MD
Center for cardiovascular and Nutrition Research (C2VN), Aix-Marseille University (France) – PhD student and Post-Doctoral fellowship
Email: pierre-andre.jarrot@childrens.harvard.edu
Started in the Wagner Lab in September 2022
Previous Research
Pierre-André has worked as assistant professor in the department of internal medicine and clinical immunology at university hospital of Marseille (France) since 2016. His research thematic is related to its clinical practice and focused on inflammatory mechanisms in small vessels vasculitis. He performed his PhD in center of cardiovascular and nutrition research (C2VN) in Aix-Marseille University, where he investigated the role of neutrophil extracellular traps in a diffuse intra alveolar hemorrhage murine model, a rare but threatening complication of vasculitis.
Previous placements
Department of Internal Medicine and Clinical Immunology, Conception’s Hospital, APHM, Marseille (France)-MD
Center for cardiovascular and Nutrition Research (C2VN), Aix-Marseille University (France) – PhD student and Post-Doctoral fellowship
Email: pierre-andre.jarrot@childrens.harvard.edu
Camila Meirelles de Souza Silva, DVM Ph.D. - Postdoctoral Fellow
Started in the Wagner Lab in December 2022
Previous Research
Camila's research interest is the integration between basic and clinical research. She obtained her Ph.D. in Pharmacology studying biomarkers in colorectal cancer. In 2022, Camila completed her Postdoctoral Fellow in Immunology investigating the role of Gasdermin D (GSDMD) in the pathophysiology of sepsis and COVID-19. She joined the Wagner lab interested in elucidating the role of the inflammasome in neutrophils and NETs.
Previous placements
University Federal do Vale do São Francisco, Brazil - DVM Doctor of Veterinary Medicine
University Federal of Ceara, Brazil - Master's degree Fellow
University Federal of Ceara, Brazil - Ph.D. Fellow
University of Sao Paulo, Brazil - Postdoctoral Fellow
Email: camila.desouzasilva@childrens.harvard.edu
Started in the Wagner Lab in December 2022
Previous Research
Camila's research interest is the integration between basic and clinical research. She obtained her Ph.D. in Pharmacology studying biomarkers in colorectal cancer. In 2022, Camila completed her Postdoctoral Fellow in Immunology investigating the role of Gasdermin D (GSDMD) in the pathophysiology of sepsis and COVID-19. She joined the Wagner lab interested in elucidating the role of the inflammasome in neutrophils and NETs.
Previous placements
University Federal do Vale do São Francisco, Brazil - DVM Doctor of Veterinary Medicine
University Federal of Ceara, Brazil - Master's degree Fellow
University Federal of Ceara, Brazil - Ph.D. Fellow
University of Sao Paulo, Brazil - Postdoctoral Fellow
Email: camila.desouzasilva@childrens.harvard.edu
Stijn Van Bruggen, Ir. - M.D., Ph.D. Candidate
Started in the Wagner lab in October 2021
Stijn came to the Wagner lab from Belgium, through a fellowship from the Belgian American Educational Foundation (B.A.E.F.). At the Wagner lab Stijn's research focuses on obesity induced chronic inflammation and how this affects neutrophil activation.
Previous research
Stijn studied the effect of neutrophil PAD4 on cardiac function with increasing age, with a specific interest in heart failure development and progression in the aging population.
Previous placements
Martinod NETs - lab, KU Leuven, Leuven, Belgium - PhD (ongoing)
KU Leuven, Leuven Belgium - Ms in Bioscience engineering with a major in molecular engineering
KU Leuven, Leuven Belgium - Bs in Bioscience engineering
E-mail: stijn.vanbruggen@childrens.harvard.edu
Started in the Wagner lab in October 2021
Stijn came to the Wagner lab from Belgium, through a fellowship from the Belgian American Educational Foundation (B.A.E.F.). At the Wagner lab Stijn's research focuses on obesity induced chronic inflammation and how this affects neutrophil activation.
Previous research
Stijn studied the effect of neutrophil PAD4 on cardiac function with increasing age, with a specific interest in heart failure development and progression in the aging population.
Previous placements
Martinod NETs - lab, KU Leuven, Leuven, Belgium - PhD (ongoing)
KU Leuven, Leuven Belgium - Ms in Bioscience engineering with a major in molecular engineering
KU Leuven, Leuven Belgium - Bs in Bioscience engineering
E-mail: stijn.vanbruggen@childrens.harvard.edu
Nicolas Schommer - Medical (MD) Student
Started in the Wagner Lab in May 2022
Previous Research
Nicolas has worked as a medical doctoral student in the working group "Platelets in Inflammation" (Prof. D. Dürschmied) at university hospital Freiburg, Germany since 2020. Pursuing his MD thesis he investigated the role of complement and platelets in myocardial ischemia and neovascularization and reticulated platelets in myocardial ischemia/reperfusion injury. He is funded by a Rudolf-Marx-Grant from the Society for Thrombosis and Haemostasis Research eV (GTH).
Previous Placements
Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Germany - MD student
E-mail: nicolas.schommer@childrens.harvard.edu
Started in the Wagner Lab in May 2022
Previous Research
Nicolas has worked as a medical doctoral student in the working group "Platelets in Inflammation" (Prof. D. Dürschmied) at university hospital Freiburg, Germany since 2020. Pursuing his MD thesis he investigated the role of complement and platelets in myocardial ischemia and neovascularization and reticulated platelets in myocardial ischemia/reperfusion injury. He is funded by a Rudolf-Marx-Grant from the Society for Thrombosis and Haemostasis Research eV (GTH).
Previous Placements
Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Germany - MD student
E-mail: nicolas.schommer@childrens.harvard.edu
Casey Sheehy, BS - Research Assistant II
Started in the Wagner Lab in March 2021
Previous Research
This is Casey's first posting in a research position in a lab.
Previous Placements
Umass Lowell, Lowell, MA, USA - BS in Biology
E-mail: casey.sheehy@childrens.harvard.edu
Started in the Wagner Lab in March 2021
Previous Research
This is Casey's first posting in a research position in a lab.
Previous Placements
Umass Lowell, Lowell, MA, USA - BS in Biology
E-mail: casey.sheehy@childrens.harvard.edu
William Chan, BS - Research Assistant I
Started in the Wagner Lab in August 2022
Previous Research
This is William's first posting in a research position in a lab.
Previous Placements
Umass Lowell, Lowell, MA, USA - BS in Biology
E-mail: william.chan@childrens.harvard.edu
Started in the Wagner Lab in August 2022
Previous Research
This is William's first posting in a research position in a lab.
Previous Placements
Umass Lowell, Lowell, MA, USA - BS in Biology
E-mail: william.chan@childrens.harvard.edu
Bruce Ewenstein, MD, PhD - Visiting Professor
Started in the Wagner Lab in November 2021
Dr. Ewenstein is a board-certified hematologist with more than 30 years of experience in academic medicine, drug development and healthcare. Dr. Ewenstein received his MD and PhD degrees from the Albert Einstein College of Medicine in New York City and did his Hematology clinical training at Brigham and Women’s Hospital.
Before joining industry in 2002, Dr. Ewenstein was an Assistant Professor of Medicine at Harvard Medical School where he served as founder and Director of the Boston Hemophilia Center (BWH/BCH) for 15 years. His doctoral and post-doctoral projects involved the structural elucidation of class I major histocompatibility (MHC) antigens. His later laboratory work centered on endothelial cell biology with a focus on the role of this cell type in hemostatic and thrombotic processes. His current interests include the roles of von Willebrand factor (VWF) and ADAMTS13 in thrombosis-inflammatory disease processes.
E-mail: bruce.ewenstein@childrens.harvard.edu
Started in the Wagner Lab in November 2021
Dr. Ewenstein is a board-certified hematologist with more than 30 years of experience in academic medicine, drug development and healthcare. Dr. Ewenstein received his MD and PhD degrees from the Albert Einstein College of Medicine in New York City and did his Hematology clinical training at Brigham and Women’s Hospital.
Before joining industry in 2002, Dr. Ewenstein was an Assistant Professor of Medicine at Harvard Medical School where he served as founder and Director of the Boston Hemophilia Center (BWH/BCH) for 15 years. His doctoral and post-doctoral projects involved the structural elucidation of class I major histocompatibility (MHC) antigens. His later laboratory work centered on endothelial cell biology with a focus on the role of this cell type in hemostatic and thrombotic processes. His current interests include the roles of von Willebrand factor (VWF) and ADAMTS13 in thrombosis-inflammatory disease processes.
E-mail: bruce.ewenstein@childrens.harvard.edu