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Wagner Lab - Cellular and Molecular Medicine

Wagner Lab
CELLULAR AND MOLECULAR MEDICINE

Thrombosis:
  • Effect of thrombus maturation and resolvins on thrombolysis
  • Inflammation and post-thrombotic syndrome
  • Role of PAD4-mediated citrullination of blood components and its effect on thrombosis
 
Wound Healing and Angiogenesis:
  • Effect of Neutrophil Extracellular Traps (NETs) and the VWF-cleaving enzyme ADAMTS13 on skin transplant and wound healing
 
Cancer: 
  • Role of PAD4 and NETs in cancer-associated venous and arterial thrombosis and systemic effects of cancer
 
Aging, inflammation, and organ fibrosis:
  • Role of the metalloproteinase ADAMTS13
  • Role of NETs and PAD4
  • Role of inflammasome

Rheumatoid Arthritis:
  • Establishing new models
  • Role of PAD4 and inflammasome
              
Cell biology of NETosis:
  • Role of various cellular organelles in the process
  • Effects of diseases that enhance NETosis on the cellular process
  • Role of NLRP3 inflammasome in NETosis​

NETs in COVID-19:
  • Participation in preparation of a clinical trial at Boston Children's Hospital and Brigham and Women's Hospital
  • Cell biology of neutrophil activation in COVID-19
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