For many years, our laboratory’s research has focused on adhesion molecules, the regulation of their expression, and their function in normal physiology and in pathological situations. We have engineered mice lacking platelet, endothelial, or leukocyte adhesion receptors and studied their phenotypes.
One of our main interests is the interplay of inflammation and thrombosis, in particular, the role of platelets and neutrophils. Recently, we have explored the impact of neutrophil extracellular traps (NETs)—decondensed chromatin coated with neutrophilic proteins—that are released from the activated neutrophils. We found an important prothrombotic role of NETs and also detrimental/toxic effects of NETs during lung injury and after myocardial infarction. We recently observed that NETs hinder wound healing in mice and found that their formation is enhanced by diabetes.