For many years, our laboratory’s research has focused on adhesion molecules, the regulation of their expression and function in normal physiology and in pathological situations. We have engineered mice lacking platelet, endothelial, or leukocyte adhesion receptors and studied their phenotypes.
One of our main interests is the interplay of inflammation and thrombosis including the role of platelets in inflammation and that of neutrophils in thrombosis. Recently we have explored the impact of neutrophil extracellular traps (NETs)-chromatin coated with granular enzymes- that is actively released from the activated neutrophils. We found an important pro-thrombotic role of NETs and also detrimental/toxic effects of NETs during lung injury and after myocardial infarction. We recently observed that NETs hinder wound healing in mice and found that their formation was enhanced by diabetes.