Publications
For more information about Denisa Wagner, please see her profile in Circulation Research, Leaders in Cardiovascular Science: www.ahajournals.org.
​
Click HERE to visit Denisa's PubMed.

2018
  • Solid peripheral tumor leads to systemic inflammation, astrocyte activation and signs of behavioral despair in mice.
           Demers M, Suidan GL, Andrews N, Martinod K, Cabral JE, Wagner DD. PLoS One. 2018 Nov 15;13(11):e0207241. [PubMed]
  • Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms.
           Wolach O, Sellar RS, Martinod K, Cherpokova D, McConkey M, Chappell RJ, Silver AJ, Adams D, Castellano CA, Schneider RK, Padera RF, DeAngelo DJ,
           Wadleigh M, Steensma DP, Galinsky I, Stone RM, Genovese G, McCarroll SA, Iliadou B, Hultman C, Neuberg D, Mullally A,  Wagner DD , Ebert BL. Sci
           Transl Med. 2018 Apr 11;10(436). [PubMed]
  • Roles of PAD4 and NETosis in experimental atherosclerosis and arterial injury: Implications for superficial erosion. Circulation research.
           Franck G, Mawson TL, Folco EJ, Ruvkun V, Engelbertsen D, Liu X, Tesmenitsky Y, Shvartz E, Wang Y, Sukhova G, Lichtman AH, Wagner DD, Nicoletti A,                     Croce K, Libby P. Circulation research. 2018 June 22;123(1):33-42. [PubMed]
  • Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma.
           Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT,
           Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD; National Heart, Lung, and Blood 
​           Institute Severe Asthma Research Program-3 Investigators. Sci Immunol. (2018) Volume: 3;3(26) [PubMed]
  • Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging.
           Wong SL, Wagner DD. FASEB J. (2018) Volume: 20  [PubMed]
  • Citrullnated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients.
           Mauracher LM, Posch F, Martinod K, Grilz E, Däullary T, Hell L, Brostjan C, Zielinski C, Ay C, Wagner DD, Pabinger I, Thaler J. JTH 2018. Volume:16.
           Pages:1- 11. [PubMed]
  •  Recombinant Human RhADAMTS13 treatment improves myocardial remodeling and functionality after pressure overload injury in mice.                   Witsch T, Martinod K, Sorvillo N, Portier I, De Meyer S, Wagner DD. JAHA. Volume: 24; 7(3) [PubMed]
  •  A key role for Rac and Pak in Neutrophil Extracellular Traps (NETs) formation defines a new potential therapeutic target                                               Gavillet, M, Martinod K, Renella R, Wagner DD, Williams D. AJH. Volume: 93(2), Pages: 269-276. [PubMed]​
2017
  • Peptidylarginine deiminase 4 promotes age-related organ fibrosis.
          Martinod K, Witsch T, Erpenbeck L, Savchenko A, Hayashi H, Cherpokova D, Gallant M, Mauler M, Cifuni SM, Wagner DD. J. Exp. Med. Volume: 214 (2),                   Pages: 439-458 (2017)
​          Click here for PDF
  • ADAMTS13 deficiency worsens colitis and exogenous ADAMTS13 administration decreases colitis severity in mice
          Zitomersky NL, Demers M, Martinod K, Gallant M, Cifuni SM, Biswas A, Snapper S, Wagner DD. TH Open. Volume: 1(1), Pages: c11-c23 (2017)  [PubMed]
  • Unraveling Vascular Inflammation: From Immunology to Imaging. 
           Teague H, Ahlman M, Alavi A, Wagner DD, Lichtman AH, Nahrendorf M, Swirski F, Nestle F, Gelfand J, Kaplan M, Grinspoon S, Ridker P, Newby D, Tawakol             A, Fayad Z, Mehta N. JACC. Volume: 70 (11), Pages: 1403-1412 (2017) [PubMed]
  • Mast cells granular contents are crucial for deep vein thrombosis in mice.
           Ponomaryov T, Payne H, Fabritz L, Wagner DD, Brill A. Circulation Research. Volume 121 (8), Pages: 941-950 (2017) [PubMed]    
  • Recombinant Human RhADAMTS13 treatment improves myocardial remodeling and functionality after pressure overload injury in mice.
           Witsch T, Martinod K, Sorvillo N, Portier I, De Meyer S, Wagner DD. JAHA. Volume: 24; 7(3) [PubMed]
  • Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.
           Hayashi H, Cherpokova D, Martinod K, Witsch T, Wong SL, Gallant M, Cifuni SM, Guarente LP, Wagner DD. PLoS One. Volume: 12 (12) (2017) [PubMed]
2016
  • PAD4 deficiency decreases inflammation and susceptibility to pregnancy loss in a mouse model. 
          Erpenbeck L, Chowdhury C, Zsengelle ZK, Gallant M, Burke SD, Cifuni S, Hahn S, Wagner DD, Karumanchi A. Biology of Reproduction. Volume: 95 (6),                       Pages:0, 1-11 (2016)
  • Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.
​          Shaw MA, Kombrinck KW, McElhinney KE, Sweet DR, Flick MJ, Palumbo JS, Cheng M, Esmon NL, Esmon CT, Brill A, Wagner DD, Degen JL, Mullins ES.
          Blood. Volume: 128 (5), Pages: 721-31 (2016) [PubMed]
  • Priming of neutrophils toward NETosis promotes tumor growth. 
          Demers M, Wong SL, Martinod K, Gallant M, Cabral JE, Wang Y, Wagner DD. 
          Oncoimmunology. Volume: 5 (5) (2016) [PubMed]
  • Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease
          Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery             RR, Shaw AC, Staeheli P, Iwasaki A. 
          Science. Volume: 352(6284), Pages: 463-6 (2016) [PubMed]
  • OC-16 - Neutrophil extracellular traps and tissue factor-bearing microvesicles: a liaison dangereuse causing overt DIC in cancer patients? 
          Hell L, Thaler J, Martinod K, Ay C, Posch F, Wagner DD, Pabinger I. 
          Thromb Res. (2016) [PubMed]
  • NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation.  
          Thålin C, Demers M, Blomgren B, Wong SL, von Arbin M, von Heijne A, Laska AC, Wallén H, Wagner DD, Aspberg S.  
          Thromb Res. Volume: 139, Pages: 56-64 [PubMed]
  • Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis. 
          Martinod K, Witsch T, Farley K, Gallant M, Remold-O'Donnell E, Wagner DD.  
           J Thromb Haemost. Volume: 14(3), Pages:551-8 (2016) [PubMed]
  • ADAMTS13 Endopeptidase Protects against Vascular Endothelial Growth Factor Inhibitor-Induced Thrombotic Microangiopathy. 
          Erpenbeck L, Demers M, Zsengellér ZK, Gallant M, Cifuni SM, Stillman IE, Karumanchi SA, Wagner DD.  
          J Am Soc Nephrol. Volume: 27(1), Pages:120-31 (2016) [PubMed]

2015 
  • Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples. 
          Gavillet M, Martinod K, Renella R, Harris C, Shapiro NI, Wagner DD, Williams DA. 
          Am J Hematol. Volume: 90(12), Pages:1155-8 (2016) [PubMed]
  • Diabetes primes neutrophils to undergo NETosis which severely impairs wound healing
          Wong SL, Martinod K, Demers M, Gallant M, Wang Y, Kahn CR, Wagner DD
          Nature Medicine (2015) [PubMed]
          Click here for PDF
  • ADAMTS13 protects against thrombotic microangiopathy in mice receiving VEGF inhibitor
    Erpenbeck L, Demers M, Zsengeller Z, Gallant M, Cifuni S, Stillman IE, Karumanchi SA, Wagner DD
    Journal of the American Society of Nephrology (2015) [PDF]
  • Dietary Omega-3 Alpha-Linolenic Acid does not prevent venous thrombosis in mice
    Reiner MF, Martinod K, Stivala S, Camici GC, Luscher TF, Wagner DD, Beer JH
    Thrombosis and haemostasis., Volume: 113, Pages: 177-84 (2015) [PubMed]
  • Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation
    Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung C, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, David M. Wilson DM
    Nature Chemical Biology, Volume: 11, Pages: 189-9 (2015) [PubMed]
  • PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock
    Martinod K, Fuchs Ta, Zitomersky NL, Wong SL, Demers M, Gallant M Wang Y, Wagner DD
    Blood, Volume: 19, Pages: 1948-56 (2015) [PubMed]
  • P-selectin promotes neutrophil extracellular trap formation in mice
    Etulain J, Martinod K, Wong SL, Cifuni SM, Schattner M, Wagner DD
    Blood, Volume: 9, Pages: 242-6 (2015) [PubMed]
          Click here for PDF
  • Tissue factor expressed by circulating cancer cell-derived microparticles drastically increases the incidence of deep vein thrombosis in mice
    Thomas GM, Brill A, Mezouar L, Crescence L, Gallant M, Dubois C, Wagner DD
    Journal of Thrombosis and Haemostasis, Volume: 13, Pages: 1310-9 (2015) [PubMed]
2014
  • VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice.
    Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD.
    Blood, Volume: 123, Pages: 141-148 (2014) [PubMed]
  • Thrombosis: Tangled up in NETs.
    Martinod K, Wagner DD
    Blood, Volume: 123, Pages: 2768-2776 (2014) [PubMed]
          Click here for PDF
  • NETosis: a new factor in tumor progression and cancer-associated thrombosis.
    Demers M, Wagner DD
    Semin Thromb Hemost, Volume: 40, Pages: 277-283 (2014) [PubMed]
  • Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development
    Savchenko AS, Martinod K, Seidman MA, Wong SL, Borissoff JI, Piazza G, Libby P, Goldhaber SZ, Mitchell RN, Wagner DD
    J Thromb Haemost, Volume: 12, Pages: 860-70 (2014) [PubMed]
  • Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease
    Chen G, Zhang D, Fuchs TA, Manwani D, Wagner DD, Frenette PS
    Blood, Volume: 123, Pages: 3818-27 (2014) [PubMed]
2013
  • Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice.
    Duerschmied D, Suidan GL, Demers M, Herr N, Carbo C, Brill A, Cifuni SM, Mauler M, Cicko S, Bader M, Idzko M, Bode C, Wagner DD.
    Blood, Volume: 121, Pages: 1008-15 (2013) [PubMed]
  • Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model.
    Carbo C, Yuki K, Demers M, Wagner DD, Shimaoka M.
    J Anesth, Volume: 27, Pages: 261-268 (2013) [PubMed]
  • Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities.
    Suidan GL, Duerschmied D, Dillon GM, Vanderhorst V, Hampton TG, Wong SL, Voorhees JR, Wagner DD.
    PLoS One, Volume: 8, Pages: e59032 (2013) [PubMed]
  • Neutrophil extracellular traps: A new link to cancer-associated thrombosis and potential implications for tumor progression.
    Demers M, Wagner DD.
    Oncoimmunology, Volume: 2, Pages: e22946 (2013) [PubMed]
  • Plasma DNA is elevated in patients with deep vein thrombosis.
    Diaz JA, Fuchs TA, Jackson TO, Hovinga JA, Lämmle B, Henke PK, Myers DD Jr, Wagner DD, Wakefield TW; for the Michigan Research Venous Group
    J Vasc Surg, Volume: 1 (2013) [PubMed]
  • Neutrophils release extracellular DNA traps during storage of red blood cell units.
    Fuchs TA, Alvarez JJ, Martinod K, Bhandari AA, Kaufman RM, Wagner DD.
    Transfusion, Volume: 53, Pages: 3210-6 (2013) [PubMed]
  • Hypoxia, such as encountered at high altitude, promotes deep vein thrombosis in mice.
    Brill A, Suidan GL, Wagner DD.
    J Thromb Haemost, Volume: 11, Pages: 1773-5 (2013) [PubMed]
  • Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.
    Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, Hu J, Wang Y, Wagner DD.
    Proc Natl Acad Sci U S A, Volume: 110, Pages: 8674-9 (2013) [PubMed]
          Click here for PDF
  • Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state.
    Borissoff JI, Joosen IA, Versteylen MO, Brill A, Fuchs TA, Savchenko AS, Gallant M, Martinod K, Ten Cate H, Hofstra L, Crijns HJ, Wagner DD, Kietselaer BL.
    Arterioscler Thromb Vasc Biol, Volume: 33, Pages: 2032-2040 (2013) [PubMed]
  • Endothelial von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice.
    Suidan GL, Brill A, De Meyer SF, Voorhees JR, Cifuni SM, Cabral JE, Wagner DD.
    Arterioscler Thromb Vasc Biol, Volume: 33, Pages: 2112-20 (2013) [PubMed]
2012
  • Targeting platelet function to improve drug delivery.
    Demers M, Wagner DD.
    OncoImmunology, Volume: 1, Pages: 100-02 (2012) [PubMed]
  • von Willebrand factor: an emerging target in stroke therapy.
    De Meyer SF, Stoll G, Wagner DD, Kleinschnitz C.
    Stroke, Volume: 43, Pages: 599-606 (2012) [PubMed]
  • Desialylation accelerates platelet clearance following refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.
    Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM
    Blood, Volume: 119, Pages: 1263-73 (2012) [PubMed]
  • Neutrophil extracellular traps promote deep vein thrombosis in mice.
    Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD.
    J Thromb Haemost, Volume: 10, Pages: 136-44 (2012) [PubMed]
  • ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion.
    Siller-Matula JM, Merhi Y, Tanguay JF, Duerschmied D, Wagner DD, McGinness KE, Pendergrast PS, Chung JK, Tian X, Schaub RG, Jilma B.
    Arterioscler Thromb Vasc Biol, Volume: 32, Pages: 902-9 (2012) [PubMed]
  • Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.
    von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Köllnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, Manukyan D, Braun S, Lange P, Riegger J, Ware J, Eckart A, Haidari S, Rudelius M, Schulz C, Echtler K, Brinkmann V, Schwaiger M, Preissner KT, Wagner DD, Mackman N, Engelmann B, Massberg S.
    J Exp Med, Volume: 209, Pages: 819-35 (2012) [PubMed]
  • Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies.
    Fuchs TA, Kremer Hovinga JA, Schatzberg D, Wagner DD, Lämmle B.
    Blood, Volume: 120, Pages: 1157-64 (2012) [PubMed]
  • Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice.
    Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD.
    Blood, Volume: 119, Pages: 6335-43 (2012) [PubMed]
          Click here for PDF
  • Extracellular chromatin is an important mediator of ischemic stroke in mice.
    De Meyer SF, Suidan GL, Fuchs TA, Monestier M, Wagner DD.
    Volume: 32, Pages: 1884-91 (2012) [PubMed]
           Click here for PDF
  • Neutrophil extracellular trap (NET) impact on deep vein thrombosis.
    Fuchs TA, Brill A, Wagner DD.
    Arterioscler Thromb Vasc Biol, Volume: 32, Pages: 1777-83 (2012) [PubMed]
  • Extrahepatic high-density lipoprotein receptor SR-BI and apoA-I protect against deep vein thrombosis in mice.
    Brill A, Yesilaltay A, De Meyer SF, Kisucka J, Fuchs TA, Kocher O, Krieger M, Wagner DD.
    Arterioscler Thromb Vasc Biol, Volume: 32, Pages: 1841-7 (2012) [PubMed]
  • Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels.
    Korin N, Kanapathipillai M, Matthews BD, Crescente M, Brill A, Mammoto T, Ghosh K, Jurek S, Bencherif SA, Bhatta D, Coskun AU, Feldman CL, Wagner DD, Ingber DE.
    Science, Volume: 337, Pages: 738-42 (2012) [PubMed]
  • Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis.
    Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT, Wagner DD.
    Proc Natl Acad Sci U S A, Volume: 106, Pages: 13076-81 (2012) [PubMed]
​          Click here for PDF
  • ADAMTS13 exerts a thrombolytic effect in microcirculation.
    Crescente M, Thomas GM, Demers M, Voorhees JR, Wong SL, Ho-Tin-Noé B, Wagner DD.
    Thromb Haemost, Volume: 108, Pages: 527-32 (2012) [PubMed]
  • Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice.
    De Meyer SF, Savchenko AS, Haas MS, Schatzberg D, Carroll MC, Schiviz A, Dietrich B, Rottensteiner H, Scheiflinger F, Wagner DD.
    Blood 2012 Dec 20;120(26):5217-23. , Volume: 120, Pages: 5217-23 (2012) [PubMed]
  • Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo.
    Chen K, Nishi H, Travers R, Tsuboi N, Martinod K, Wagner DD, Stan R, Croce K, Mayadas TN.
    Blood , Volume: 120, Pages: 4421-31 (2012) [PubMed]
2011
  • Increased efficacy of breast cancer chemotherapy in thrombocytopenic mice.
    Demers M, Ho-Tin-Noé B, Schatzberg D, Yang JJ, Wagner DD
    Cancer Res, Volume: 71 , Pages: 1540-9 (2011) [PubMed]
  • von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models.
    Brill A, Fuchs TA, Chauhan AK, Yang JJ, De Meyer SF, Köllnberger M, Wakefield TW, Lämmle B, Massberg S, Wagner DD.
    Blood., Volume: 117, Pages: 1400-7 (2011) [PubMed]
  • The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.
    Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD and Degen JL
    Blood., Volume: 117, Pages: 6326-6337 (2011) [PubMed]
  • Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling.
    Stadtmann A, Brinkhaus L, Mueller H, Rossaint J, Bolomini-Vittori M, Bergmeier W, Van Aken H, Wagner DD, Laudanna C, Ley K, Zarbock A.
    Eur J Immunol, Volume: 41, Pages: 2074-2085 (2011) [PubMed]
  • Histones induce rapid and profound thrombocytopenia in mice.
    Fuchs TA, Bhandari AA, Wagner DD.
    Blood, Volume: 118, Pages: 3708-3714 (2011) [PubMed]
  • How platelets safeguard vascular integrity.
    Ho-Tin-Noé B, Demers M, Wagner DD.
    J Thromb Haemost, Volume: 9 , Pages: 56-65 (2011) [PubMed]
  • Platelet glycoprotein Ibalpha is an important mediator of ischemic stroke in mice.
    De Meyer SF, Scwharz T, Schatzberg D, Wagner DD.
    Exp Transl Stroke Med, Volume: 3, Pages: 9 (2011) [PubMed]
2010
  • p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo.
    Canault M, Duerschmied D, Brill A, Stefanini L. Schatzberg D, Cifuni SM, Bergmeier, Wagner DD
    Blood, Volume: 115, Pages: 1835-42 (2010) [PubMed]
  • Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.
    Carbo C, Duerschmied D, Goerge T, Hattori H, Sakai J, Cifuni SM, White II GC, Chrzanowska-Wodnicka M, Luo HR, Wagner DD
    J Leukoc Biol, , Volume: 88, Pages: 313-19 (2010) [PubMed]
  • The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation.
    Canault M, Certel K, Schatzberg D, Wagner DD, Hynes RO.
    PLoS One. , Volume: 5, Pages: e13433 (2010) [PubMed]
  • A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.
    Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH.
    J Exp Med, Volume: 207, Pages: 1967-79 (2010) [PubMed]
  • Extracellular DNA traps promote thrombosis.
    Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD Jr, Wrobleski SK, Wakefield TW, Hartwig JH, Wagner DD.
    Proc Natl Acad Sci U S A. , Volume: 107, Pages: 15880-5 (2010) [PubMed]
          Click here for PDF
2009
  • The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation.
    Banno F, Chauhan AK, Kokame K, Yang J, Miyata S, Wagner DD, and Miyata T.
    Blood, Volume: 113, Pages: 5323-5329 (2009) [PubMed]
  • Differential stimulation of monocytic cells results in distinct populations of microparticles.
    Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD.
    J Thromb Haemost, Volume: 7, Pages: 1019-1028 (2009) [PubMed]
  • Structure, biology and genetics of von Willebrand factor.
    Ginsburg D and Wagner DD. Structure, biology and genetics of von Willebrand factor.
    In: Hematology: Basic Principles and Practices. 5th Edition. Hoffman R, Benz EJ, Shattil SJ, Furie B, Silberstein LE, McGlave P, Heslop H. (Eds.). NY: Churchill Livingstone (2009)
  • Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis.
    Kisucka J, Chauhan AK, Zhao BQ, Patten IS, Yesilaltay A, Krieger M, Wagner DD.
    Blood, Volume: 113, Pages: 6015-6022 (2009) [PubMed]
  • Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779.
    Diener JL, Daniel Lagasse HA, Duerschmied D, Merhi Y, Tanguay JF, Hutabarat R, Gilbert J, Wagner DD, Schaub R.
    J Thromb Haemost, Volume: 7, Pages: 1155-1162 (2009) [PubMed]
  • Serotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17).
    Duerschmied D, Canault M, Lievens D, Brill A, Cifuni SM, Bader M, Wagner DD.
    J Thromb Haemost, Volume: 7, Pages: 1163-1171 (2009) [PubMed]
  • Platelets: guardians of tumor vasculature.
    Ho-Tin-Noe B, Goerge T, Wagner DD.
    Cancer Res, Volume: 69, Pages: 5623-5626 (2009) [PubMed]
  • Inhibition of VEGF or TGF-{beta} signaling activates endothelium and increases leukocyte rolling.
    Walshe TE, Dole VS, Maharaj AS, Patten IS, Wagner DD, D'Amore PA.
    Arterioscler Thromb Vasc Biol, Volume: 29, Pages: 1185-1192 (2009) [PubMed]
  • Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion.
    Brill A, Chauhan AK, Canault M, Walsh MT, Bergmeier W, Wagner DD.
    Cardiovasc Res, Volume: 84, Pages: 137-144 (2009) [PubMed]
  • Innate immune cells induce hemorrhage in tumors during thrombocytopenia.
    Ho-Tin-Noé B, Carbo C, Demers M, Cifuni SM, Goerge T, Wagner DD.
    Am J Path, Volume: 175, Pages: 1699-708 (2009) [PubMed]
  • von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke.
    Zhao BQ, Chauhan AK, Canault M, Patten IS, Yang JJ, Dockal M, Scheiflinger F, Wagner DD.
    Blood, Volume: 114, Pages: 3329-34 (2009) [PubMed]
2008
  • CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets
    Cifuni, S. M.; Wagner, D. D.; Bergmeier, W.
    Blood, Volume: 112, Pages: 1696-703 (2008) [PubMed]
  • The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis
    Chauhan, A. K.; Walsh, M. T.; Zhu, G.; Ginsburg, D.; Wagner, D. D.; Motto, D. G.
    Blood, Volume: 111, Pages: 3452-7 (2008) [PubMed]
  • Prothrombotic effects of fibronectin isoforms containing the EDA domain
    Chauhan, A. K.; Kisucka, J.; Cozzi, M. R.; Walsh, M. T.; Moretti, F. A.; Battiston, M.; Mazzucato, M.; De Marco, L.; Baralle, F. E.; Wagner, D. D.; Muro, A. F.
    Arterioscler Thromb Vasc Biol, Volume: 28, Pages: 296-301 (2008) [PubMed]
  • The effect of C1 inhibitor on intestinal ischemia and reperfusion injury
    Lu, F.; Chauhan, A. K.; Fernandes, S. M.; Walsh, M. T.; Wagner, D. D.; Davis 3rd, A. E.
    Am J Physiol Gastrointest Liver Physiol (2008) [PubMed]
  • Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis
    Kisucka, J.; Chauhan, A. K.; Patten, I. S.; Yesilaltay, A.; Neumann, C.; Van Etten, R. A.; Krieger, M.; Wagner, D. D.
    Circ Res, Volume: 103, Pages: 598-605 (2008) [PubMed]
  • Platelet granule secretion continuously prevents intratumor hemorrhage
    Ho-Tin-Noe, B.; Goerge, T.; Cifuni, S. M.; Duerschmied, D.; Wagner, D. D.
    Cancer Res, Volume: 68, Pages: 6851-8 (2008) [PubMed]
  • Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice
    Dole, V. S.; Matuskova, J.; Vasile, E.; Yesilaltay, A.; Bergmeier, W.; Bernimoulin, M.; Wagner, D. D.; Krieger, M.
    Arterioscler Thromb Vasc Biol, Volume: 28, Pages: 1111-6 (2008) [PubMed]
  • Glycoprotein Ibalpha and von Willebrand factor in primary platelet adhesion and thrombus formation: lessons from mutant mice
    Bergmeier, W.; Chauhan, A. K.; Wagner, D. D.
    Thromb Haemost, Volume: 99, Pages: 264-70 (2008) [PubMed]
  • The vessel wall and its interactions
    Wagner, D. D.; Frenette, P. S.
    Blood, Volume: 111, Pages: 5271-81 (2008) [PubMed]
  • Inflammation induces hemorrhage in thrombocytopenia
    Goerge, T.; Ho-Tin-Noe, B.; Carbo, C.; Benarafa, C.; Remold-O'Donnell, E.; Zhao, B. Q.; Cifuni, S. M.; Wagner, D. D.
    Blood, Volume: 111, Pages: 4958-64 (2008) [PubMed]
  • von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis
    Noubade, R.; del Rio, R.; McElvany, B.; Zachary, J. F.; Millward, J. M.; Wagner, D. D.; Offner, H.; Blankenhorn, E. P.; Teuscher, C.
    Am J Pathol, Volume: 173, Pages: 892-900 (2008) [PubMed]
  • ADAMTS13: a new link between thrombosis and inflammation
    Chauhan, A. K.; Kisucka, J.; Brill, A.; Walsh, M. T.; Scheiflinger, F.; Wagner, D. D.
    J Exp Med, Volume: 205, Pages: 2065-74 (2008) [PubMed]
2007
  • Formation of platelet strings and microthrombi in the presence of ADAMTS-13 inhibitor does not require P-selectin or beta3 integrin
    Chauhan, A. K.; Goerge, T.; Schneider, S. W.; Wagner, D. D.
    J Thromb Haemost, Volume: 5, Pages: 583-9 (2007) [PubMed]
  • Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury
    Zhu, L.; Bergmeier, W.; Wu, J.; Jiang, H.; Stalker, T. J.; Cieslak, M.; Fan, R.; Boumsell, L.; Kumanogoh, A.; Kikutani, H.; Tamagnone, L.; Wagner, D. D.; Milla, M. E.; Brass, L. F.
    Proc Natl Acad Sci U S A, Volume: 104, Pages: 1621-6 (2007) [PubMed]
  • ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage
    Hafezi-Moghadam, A.; Thomas, K. L.; Wagner, D. D.
    Am J Physiol Cell Physiol, Volume: 292, Pages: C1256-62 (2007) [PubMed]
  • Alteromonas tagae sp. nov. and Alteromonas simiduii sp. nov., mercury-resistant bacteria isolated from a Taiwanese estuary
    Chiu, H. H.; Shieh, W. Y.; Lin, S. Y.; Tseng, C. M.; Chiang, P. W.; Wagner-Dobler, I.
    Int J Syst Evol Microbiol, Volume: 57, Pages: 1209-16 (2007) [PubMed]
  • von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins
    Chauhan, A. K.; Kisucka, J.; Lamb, C. B.; Bergmeier, W.; Wagner, D. D.
    Blood, Volume: 109, Pages: 2424-9 (2007) [PubMed]
  • PSGL-1 regulates platelet P-selectin-mediated endothelial activation and shedding of P-selectin from activated platelets
    Dole, V. S.; Bergmeier, W.; Patten, I. S.; Hirahashi, J.; Mayadas, T. N.; Wagner, D. D.
    Thromb Haemost, Volume: 98, Pages: 806-12 (2007) [PubMed]
  • Platelet adhesion receptors and their ligands in mouse models of thrombosis
    Denis, C. V.; Wagner, D. D.
    Arterioscler Thromb Vasc Biol, Volume: 27, Pages: 728-39 (2007) [PubMed]
  • Dynamic visualization of thrombopoiesis within bone marrow
    Junt, T.; Schulze, H.; Chen, Z.; Massberg, S.; Goerge, T.; Krueger, A.; Wagner, D. D.; Graf, T.; Italiano, J. E., Jr.; Shivdasani, R. A.; von Andrian, U. H.
    Science, Volume: 317, Pages: 1767-70 (2007) [PubMed]
  • Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III
    Bergmeier, W.; Goerge, T.; Wang, H. W.; Crittenden, J. R.; Baldwin, A. C.; Cifuni, S. M.; Housman, D. E.; Graybiel, A. M.; Wagner, D. D.
    J Clin Invest, Volume: 117, Pages: 1699-707 (2007) [PubMed]
  • In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration
    Babic, A. M.; Josefsson, E. C.; Bergmeier, W.; Wagner, D. D.; Kaufman, R. M.; Silberstein, L. E.; Stossel, T. P.; Hartwig, J. H.; Hoffmeister, K. M.
    Transfusion, Volume: 47, Pages: 442-51 (2007) [PubMed]
  • Platelet adhesion receptors do not modulate infarct volume after a photochemically induced stroke in mice
    Frederix, K.; Chauhan, A. K.; Kisucka, J.; Zhao, B. Q.; Hoff, E. I.; Spronk, H. M.; Ten Cate, H.; Wagner, D. D.
    Brain Res, Volume: 1185, Pages: 239-45 (2007) [PubMed]
2006
  • Systemic antithrombotic effects of ADAMTS13
    Chauhan, A. K.; Motto, D. G.; Lamb, C. B.; Bergmeier, W.; Dockal, M.; Plaimauer, B.; Scheiflinger, F.; Ginsburg, D.; Wagner, D. D.
    J Exp Med, Volume: 203, Pages: 767-76 (2006) [PubMed]
  • Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy
    Hirahashi, J.; Mekala, D.; Van Ziffle, J.; Xiao, L.; Saffaripour, S.; Wagner, D. D.; Shapiro, S. D.; Lowell, C.; Mayadas, T. N.
    Immunity, Volume: 25, Pages: 271-83 (2006) [PubMed]
  • Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage
    Kisucka, J.; Butterfield, C. E.; Duda, D. G.; Eichenberger, S. C.; Saffaripour, S.; Ware, J.; Ruggeri, Z. M.; Jain, R. K.; Folkman, J.; Wagner, D. D.
    Proc Natl Acad Sci U S A, Volume: 103, Pages: 855-60 (2006) [PubMed]
  • The A2B adenosine receptor protects against inflammation and excessive vascular adhesion
    Yang, D.; Zhang, Y.; Nguyen, H. G.; Koupenova, M.; Chauhan, A. K.; Makitalo, M.; Jones, M. R.; St Hilaire, C.; Seldin, D. C.; Toselli, P.; Lamperti, E.; Schreiber, B. M.; Gavras, H.; Wagner, D. D.; Ravid, K.
    J Clin Invest, Volume: 116, Pages: 1913-23 (2006) [PubMed]
  • The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
    Bergmeier, W.; Piffath, C. L.; Goerge, T.; Cifuni, S. M.; Ruggeri, Z. M.; Ware, J.; Wagner, D. D.
    Proc Natl Acad Sci U S A, Volume: 103, Pages: 16900-5 (2006) [PubMed]
  • Elevated levels of homocysteine compromise blood-brain barrier integrity in mice
    Kamath, A. F.; Chauhan, A. K.; Kisucka, J.; Dole, V. S.; Loscalzo, J.; Handy, D. E.; Wagner, D. D.
    Blood, Volume: 107, Pages: 591-3 (2006) [PubMed]
  • Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo
    Yang, H.; Reheman, A.; Chen, P.; Zhu, G.; Hynes, R. O.; Freedman, J.; Wagner, D. D.; Ni, H.
    J Thromb Haemost, Volume: 4, Pages: 2230-7 (2006) [PubMed]
  • Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles
    Matuskova, J.; Chauhan, A. K.; Cambien, B.; Astrof, S.; Dole, V. S.; Piffath, C. L.; Hynes, R. O.; Wagner, D. D.
    Arterioscler Thromb Vasc Biol, Volume: 26, Pages: 1391-6 (2006) [PubMed]
  • Inflammation.
    Bergmeier W and Wagner DD.
    In: Platelets. 2nd Edition. Michelson A (Ed.) San Diego: Elsevier – Academic Press (2006)
2005
  • Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin
    Dole, V. S.; Bergmeier, W.; Mitchell, H. A.; Eichenberger, S. C.; Wagner, D. D.
    Blood, Volume: 106, Pages: 2334-9 (2005) [PubMed]
  • Aspirin induces platelet receptor shedding via ADAM17 (TACE)
    Aktas, B.; Pozgajova, M.; Bergmeier, W.; Sunnarborg, S.; Offermanns, S.; Lee, D.; Wagner, D. D.; Nieswandt, B.
    J Biol Chem, Volume: 280, Pages: 39716-22 (2005) [PubMed]
  • The P-selectin, tissue factor, coagulation triad
    Polgar, J.; Matuskova, J.; Wagner, D. D.
    J Thromb Haemost, Volume: 3, Pages: 1590-6 (2005) [PubMed]
  • A direct role for C1 inhibitor in regulation of leukocyte adhesion
    Cai, S.; Dole, V. S.; Bergmeier, W.; Scafidi, J.; Feng, H.; Wagner, D. D.; Davis, A. E., 3rd
    J Immunol, Volume: 174, Pages: 6462-6 (2005) [PubMed]
  • New links between inflammation and thrombosis
    Wagner, D. D.
    Arterioscler Thromb Vasc Biol, Volume: 25, Pages: 1321-4 (2005) [PubMed]
  • Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice
    Motto, D. G.; Chauhan, A. K.; Zhu, G.; Homeister, J.; Lamb, C. B.; Desch, K. C.; Zhang, W.; Tsai, H. M.; Wagner, D. D.; Ginsburg, D.
    J Clin Invest, Volume: 115, Pages: 2752-61 (2005) [PubMed]
  • Elevated soluble ICAM-1 levels induce immune deficiency and increase adiposity in mice
    Wang, H. W.; Babic, A. M.; Mitchell, H. A.; Liu, K.; Wagner, D. D.
    FASEB J, Volume: 19, Pages: 1018-20 (2005) [PubMed]
2004
  • A new role in hemostasis for the adhesion receptor P-selectin
    Cambien, B.; Wagner, D. D.
    Trends Mol Med, Volume: 10, Pages: 179-86 (2004) [PubMed]
  • ICAM-1 and beta2 integrin deficiency impairs fat oxidation and insulin metabolism during fasting
    Babic, A. M.; Wang, H. W.; Lai, M. J.; Daniels, T. G.; Felbinger, T. W.; Burger, P. C.; Stricker-Krongrad, A.; Wagner, D. D.
    Mol Med, Volume: 10, Pages: 72-9 (2004) [PubMed]
  • CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
    Crittenden, J. R.; Bergmeier, W.; Zhang, Y.; Piffath, C. L.; Liang, Y.; Wagner, D. D.; Housman, D. E.; Graybiel, A. M.
    Nat Med, Volume: 10, Pages: 982-6 (2004) [PubMed]
  • Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier
    Kondo, T.; Hafezi-Moghadam, A.; Thomas, K.; Wagner, D. D.; Kahn, C. R.
    Biochem Biophys Res Commun, Volume: 317, Pages: 315-20 (2004) [PubMed]
  • GPVI down-regulation in murine platelets through metalloproteinase-dependent shedding
    Bergmeier, W.; Rabie, T.; Strehl, A.; Piffath, C. L.; Prostredna, M.; Wagner, D. D.; Nieswandt, B.
    Thromb Haemost, Volume: 91, Pages: 951-8 (2004) [PubMed]
  • Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo
    Bergmeier, W.; Piffath, C. L.; Cheng, G.; Dole, V. S.; Zhang, Y.; von Andrian, U. H.; Wagner, D. D.
    Circ Res, Volume: 95, Pages: 677-83 (2004) [PubMed]
  • Structure, biology and genetics of von Willebrand factor.
    Ginsburg D and Wagner DD.
    In: Hematology: Basic Principles and Practices. 4th Edition. Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE and McGlave P. (Eds.). New York: Churchill Livingstone (2004)
2003
  • Antithrombotic activity of TNF-alpha
    Cambien, B.; Bergmeier, W.; Saffaripour, S.; Mitchell, H. A.; Wagner, D. D.
    J Clin Invest, Volume: 112, Pages: 1589-96 (2003) [PubMed]
  • Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor
    Matsushita, K.; Morrell, C. N.; Cambien, B.; Yang, S. X.; Yamakuchi, M.; Bao, C.; Hara, M. R.; Quick, R. A.; Cao, W.; O'Rourke, B.; Lowenstein, J. M.; Pevsner, J.; Wagner, D. D.; Lowenstein, C. J.
    Cell, Volume: 115, Pages: 139-50 (2003) [PubMed]
  • The clearance mechanism of chilled blood platelets
    Hoffmeister, K. M.; Felbinger, T. W.; Falet, H.; Denis, C. V.; Bergmeier, W.; Mayadas, T. N.; von Andrian, U. H.; Wagner, D. D.; Stossel, T. P.; Hartwig, J. H.
    Cell, Volume: 112, Pages: 87-97 (2003) [PubMed]
  • Plasma fibronectin promotes thrombus growth and stability in injured arterioles
    Ni, H.; Yuen, P. S.; Papalia, J. M.; Trevithick, J. E.; Sakai, T.; Fassler, R.; Hynes, R. O.; Wagner, D. D.
    Proc Natl Acad Sci U S A, Volume: 100, Pages: 2415-9 (2003) [PubMed]
  • Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A
    Hrachovinova, I.; Cambien, B.; Hafezi-Moghadam, A.; Kappelmayer, J.; Camphausen, R. T.; Widom, A.; Xia, L.; Kazazian, H. H., Jr.; Schaub, R. G.; McEver, R. P.; Wagner, D. D.
    Nat Med, Volume: 9, Pages: 1020-5 (2003) [PubMed]
  • P-selectin and leukocyte microparticles are associated with venous thrombogenesis
    Myers, D. D.; Hawley, A. E.; Farris, D. M.; Wrobleski, S. K.; Thanaporn, P.; Schaub, R. G.; Wagner, D. D.; Kumar, A.; Wakefield, T. W.
    J Vasc Surg, Volume: 38, Pages: 1075-89 (2003) [PubMed]
  • Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets
    Bergmeier, W.; Burger, P. C.; Piffath, C. L.; Hoffmeister, K. M.; Hartwig, J. H.; Nieswandt, B.; Wagner, D. D.
    Blood, Volume: 102, Pages: 4229-35 (2003) [PubMed]
  • Mechanisms and implications of platelet discoid shape
    Italiano, J. E., Jr.; Bergmeier, W.; Tiwari, S.; Falet, H.; Hartwig, J. H.; Hoffmeister, K. M.; Andre, P.; Wagner, D. D.; Shivdasani, R. A.
    Blood, Volume: 101, Pages: 4789-96 (2003) [PubMed]
  • Platelets in inflammation and thrombosis
    Wagner, D. D.; Burger, P. C.
    Arterioscler Thromb Vasc Biol, Volume: 23, Pages: 2131-7 (2003) [PubMed]
  • Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain
    Ni, H.; Papalia, J. M.; Degen, J. L.; Wagner, D. D.
    Blood, Volume: 102, Pages: 3609-14 (2003) [PubMed]
  • Platelet P-selectin facilitates atherosclerotic lesion development
    Burger, P. C.; Wagner, D. D.
    Blood, Volume: 101, Pages: 2661-6 (2003) [PubMed]
  • Shear madness in TNF-alpha signaling.
    Wagner DD.
    Blood, Volume: 102, Pages: 2711-2712 (2003)
2002
  • Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPAR alpha
    Sethi, S.; Ziouzenkova, O.; Ni, H.; Wagner, D. D.; Plutzky, J.; Mayadas, T. N.
    Blood, Volume: 100, Pages: 1340-6 (2002) [PubMed]
  • Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature
    Gotte, M.; Joussen, A. M.; Klein, C.; Andre, P.; Wagner, D. D.; Hinkes, M. T.; Kirchhof, B.; Adamis, A. P.; Bernfield, M.
    Invest Ophthalmol Vis Sci, Volume: 43, Pages: 1135-41 (2002) [PubMed]
  • CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism
    Andre, P.; Prasad, K. S.; Denis, C. V.; He, M.; Papalia, J. M.; Hynes, R. O.; Phillips, D. R.; Wagner, D. D.
    Nat Med, Volume: 8, Pages: 247-52 (2002) [PubMed]
2001
  • Interleukin 11 significantly increases plasma von Willebrand factor and factor VIII in wild type and von Willebrand disease mouse models
    Denis, C. V.; Kwack, K.; Saffaripour, S.; Maganti, S.; Andre, P.; Schaub, R. G.; Wagner, D. D.
    Blood, Volume: 97, Pages: 465-72 (2001) [PubMed]
  • Localized reduction of atherosclerosis in von Willebrand factor-deficient mice
    Methia, N.; Andre, P.; Denis, C. V.; Economopoulos, M.; Wagner, D. D.
    Blood, Volume: 98, Pages: 1424-8 (2001) [PubMed]
  • ApoE deficiency compromises the blood brain barrier especially after injury
    Methia, N.; Andre, P.; Hafezi-Moghadam, A.; Economopoulos, M.; Thomas, K. L.; Wagner, D. D.
    Mol Med, Volume: 7, Pages: 810-5 (2001) [PubMed]
  • Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice
    Denis, C. V.; Andre, P.; Saffaripour, S.; Wagner, D. D.
    Proc Natl Acad Sci U S A, Volume: 98, Pages: 4072-7 (2001) [PubMed]
  • Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice
    Niederman, R.; Westernoff, T.; Lee, C.; Mark, L. L.; Kawashima, N.; Ullman-Culler, M.; Dewhirst, F. E.; Paster, B. J.; Wagner, D. D.; Mayadas, T.; Hynes, R. O.; Stashenko, P.
    J Clin Periodontol, Volume: 28, Pages: 569-75 (2001) [PubMed]
  • Increased thrombogenesis and embolus formation in mice lacking glycoprotein V
    Ni, H.; Ramakrishnan, V.; Ruggeri, Z. M.; Papalia, J. M.; Phillips, D. R.; Wagner, D. D.
    Blood, Volume: 98, Pages: 368-73 (2001) [PubMed]
2000
  • Pro-coagulant state resulting from high levels of soluble P-selectin in blood
    Andre, P.; Hartwell, D.; Hrachovinova, I.; Saffaripour, S.; Wagner, D. D.
    Proc Natl Acad Sci U S A, Volume: 97, Pages: 13835-40 (2000) [PubMed]
  • Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen
    Ni, H.; Denis, C. V.; Subbarao, S.; Degen, J. L.; Sato, T. N.; Hynes, R. O.; Wagner, D. D.
    J Clin Invest, Volume: 106, Pages: 385-92 (2000) [PubMed]
  • Prominent role of P-selectin in the development of advanced atherosclerosis in ApoE-deficient mice
    Dong, Z. M.; Brown, A. A.; Wagner, D. D.
    Circulation, Volume: 101, Pages: 2290-5 (2000) [PubMed]
  • Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins
    Andre, P.; Denis, C. V.; Ware, J.; Saffaripour, S.; Hynes, R. O.; Ruggeri, Z. M.; Wagner, D. D.
    Blood, Volume: 96, Pages: 3322-8 (2000) [PubMed]
  • P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo
    Frenette, P. S.; Denis, C. V.; Weiss, L.; Jurk, K.; Subbarao, S.; Kehrel, B.; Hartwig, J. H.; Vestweber, D.; Wagner, D. D.
    J Exp Med, Volume: 191, Pages: 1413-22 (2000) [PubMed]
1999
  • Insights from von Willebrand disease animal models
    Denis, C. V.; Wagner, D. D.
    Cell Mol Life Sci, Volume: 56, Pages: 977-90 (1999) [PubMed]
  • Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions
    Jia, G. Q.; Gonzalo, J. A.; Hidalgo, A.; Wagner, D.; Cybulsky, M.; Gutierrez-Ramos, J. C.
    Int Immunol, Volume: 11, Pages: 1-10 (1999) [PubMed]
  • New discoveries with mice mutant in endothelial and platelet selectins
    Hartwell, D. W.; Wagner, D. D.
    Thromb Haemost, Volume: 82, Pages: 850-7 (1999) [PubMed]
  • Carboxypeptidase E does not mediate von Willebrand factor targeting to storage granules
    Methia, N.; Denis, C. V.; Wagner, D. D.
    Eur J Cell Biol, Volume: 78, Pages: 884-91 (1999) [PubMed]
  • Donor MHC and adhesion molecules in transplant arteriosclerosis
    Shi, C.; Feinberg, M. W.; Zhang, D.; Patel, A.; Sim, C. U.; Dong, Z. M.; Chapman, S. M.; Gutierrez-Ramos, J. C.; Wagner, D. D.; Sibinga, N. E.; Haber, E.
    J Clin Invest, Volume: 103, Pages: 469-74 (1999) [PubMed]
  • Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
    Enjyoji, K.; Sevigny, J.; Lin, Y.; Frenette, P. S.; Christie, P. D.; Esch, J. S., 2nd; Imai, M.; Edelberg, J. M.; Rayburn, H.; Lech, M.; Beeler, D. L.; Csizmadia, E.; Wagner, D. D.; Robson, S. C.; Rosenberg, R. D.
    Nat Med, Volume: 5, Pages: 1010-7 (1999) [PubMed]
  • P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury
    Soriano, S. G.; Wang, Y. F.; Wagner, D. D.; Frenette, P. S.
    Brain Res, Volume: 835, Pages: 360-4 (1999) [PubMed]
  • Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment
    Robinson, S. D.; Frenette, P. S.; Rayburn, H.; Cummiskey, M.; Ullman-Cullere, M.; Wagner, D. D.; Hynes, R. O.
    Proc Natl Acad Sci U S A, Volume: 96, Pages: 11452-7 (1999) [PubMed]
  • Structure, biology and genetics of von Willebrand factor.
    Ginsburg D and Wagner DD.
    In: Hematology: Basic Principles and Practices. 3rd Edition. Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE and McGlave P. (Eds.). New York: Churchill Livingstone (1999)
1998
  • Platelet-endothelial interactions in inflamed mesenteric venules
    Frenette, P. S.; Moyna, C.; Hartwell, D. W.; Lowe, J. B.; Hynes, R. O.; Wagner, D. D.
    Blood, Volume: 91, Pages: 1318-24 (1998) [PubMed]
  • A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis
    Denis, C.; Methia, N.; Frenette, P. S.; Rayburn, H.; Ullman-Cullere, M.; Hynes, R. O.; Wagner, D. D.
    Proc Natl Acad Sci U S A, Volume: 95, Pages: 9524-9 (1998) [PubMed]
  • Angiogenesis in P- and E-selectin-deficient mice
    Hartwell, D. W.; Butterfield, C. E.; Frenette, P. S.; Kenyon, B. M.; Hynes, R. O.; Folkman, J.; Wagner, D. D.
    Microcirculation, Volume: 5, Pages: 173-8 (1998) [PubMed]
  • Leukocyte-endothelium adhesion molecules in atherosclerosis
    Dong, Z. M.; Wagner, D. D.
    J Lab Clin Med, Volume: 132, Pages: 369-75 (1998) [PubMed]
  • P-Selectin and platelet clearance
    Berger, G.; Hartwell, D. W.; Wagner, D. D.
    Blood, Volume: 92, Pages: 4446-52 (1998) [PubMed]
  • The transmembrane domain enhances granular targeting of P-selectin
    Fleming, J. C.; Berger, G.; Guichard, J.; Cramer, E. M.; Wagner, D. D.
    Eur J Cell Biol, Volume: 75, Pages: 331-43 (1998) [PubMed]
  • P- and E-selectins are required for the leukocyte recruitment, but not the tissue swelling, associated with IgE- and mast cell-dependent inflammation in mouse skin
    de Mora, F.; Williams, C. M.; Frenette, P. S.; Wagner, D. D.; Hynes, R. O.; Galli, S. J.
    Lab Invest, Volume: 78, Pages: 497-505 (1998) [PubMed]
  • The combined role of P- and E-selectins in atherosclerosis
    Dong, Z. M.; Chapman, S. M.; Brown, A. A.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.
    J Clin Invest, Volume: 102, Pages: 145-52 (1998) [PubMed]
  • Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow
    Frenette, P. S.; Subbarao, S.; Mazo, I. B.; von Andrian, U. H.; Wagner, D. D.
    Proc Natl Acad Sci U S A, Volume: 95, Pages: 14423-8 (1998) [PubMed]
  • Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses
    Hartwell, D. W.; Mayadas, T. N.; Berger, G.; Frenette, P. S.; Rayburn, H.; Hynes, R. O.; Wagner, D. D.
    J Cell Biol, Volume: 143, Pages: 1129-41 (1998) [PubMed]
  • Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1
    Mazo, I. B.; Gutierrez-Ramos, J. C.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.; von Andrian, U. H.
    J Exp Med, Volume: 188, Pages: 465-74 (1998) [PubMed]
  • Leukocytes fighting against obesity
    Dong, Z. M.; Wagner, D. D.
    Mol Psychiatry, Volume: 3, Pages: 8-9 (1998) [PubMed]
  • E and P selectins are not required for resistance to severe murine lyme arthritis
    Seiler, K. P.; Ma, Y.; Weis, J. H.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.; Weis, J. J.
    Infect Immun, Volume: 66, Pages: 4557-9 (1998) [PubMed]
  • Overlapping functions of E- and P-selectin in neutrophil recruitment during acute inflammation
    Homeister, J. W.; Zhang, M.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.; Lowe, J. B.; Marks, R. M.
    Blood, Volume: 92, Pages: 2345-52 (1998) [PubMed]
1997
  • Genetic manipulation of vascular adhesion molecules in mice
    Hynes, R. O.; Wagner, D. D.
    J Clin Invest, Volume: 100, Pages: S11-3 (1997) [PubMed]
  • A new class of obesity genes encodes leukocyte adhesion receptors
    Dong, Z. M.; Gutierrez-Ramos, J. C.; Coxon, A.; Mayadas, T. N.; Wagner, D. D.
    Proc Natl Acad Sci U S A, Volume: 94, Pages: 7526-30 (1997) [PubMed]
  • Role of endothelial selectins in wound repair
    Subramaniam, M.; Saffaripour, S.; Van De Water, L.; Frenette, P. S.; Mayadas, T. N.; Hynes, R. O.; Wagner, D. D.
    Am J Pathol, Volume: 150, Pages: 1701-9 (1997) [PubMed]
  • Insights into selectin function from knockout mice
    Frenette, P. S.; Wagner, D. D.
    Thromb Haemost, Volume: 78, Pages: 60-4 (1997) [PubMed]
  • Generation and characterization of a novel adhesion function blocking monoclonal antibody recognizing both rat and mouse E-selectin
    Walter, U. M.; Ayer, L. M.; Manning, A. M.; Frenette, P. S.; Wagner, D. D.; Hynes, R. O.; Wolitzky, B. A.; Issekutz, A. C.
    Hybridoma, Volume: 16, Pages: 355-61 (1997) [PubMed]
  • Characterization of a novel adhesion function blocking monoclonal antibody to rat/mouse P-selectin generated in the P-selectin-deficient mouse
    Walter, U. M.; Ayer, L. M.; Wolitzky, B. A.; Wagner, D. D.; Hynes, R. O.; Manning, A. M.; Issekutz, A. C.
    Hybridoma, Volume: 16, Pages: 249-57 (1997) [PubMed]
  • Experimental murine acid aspiration injury is mediated by neutrophils and the alternative complement pathway
    Weiser, M. R.; Pechet, T. T.; Williams, J. P.; Ma, M.; Frenette, P. S.; Moore, F. D.; Kobzik, L.; Hines, R. O.; Wagner, D. D.; Carroll, M. C.; Hechtman, H. B.
    J Appl Physiol, Volume: 83, Pages: 1090-5 (1997) [PubMed]
  • Absence of P-selectin delays fatty streak formation in mice
    Johnson, R. C.; Chapman, S. M.; Dong, Z. M.; Ordovas, J. M.; Mayadas, T. N.; Herz, J.; Hynes, R. O.; Schaefer, E. J.; Wagner, D. D.
    J Clin Invest, Volume: 99, Pages: 1037-43 (1997) [PubMed]
1996
  • Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins
    Tang, T.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.; Mayadas, T. N.
    J Clin Invest, Volume: 97, Pages: 2485-90 (1996) [PubMed]
  • Defects in hemostasis in P-selectin-deficient mice
    Subramaniam, M.; Frenette, P. S.; Saffaripour, S.; Johnson, R. C.; Hynes, R. O.; Wagner, D. D.
    Blood, Volume: 87, Pages: 1238-42 (1996) [PubMed]
  • Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation
    Pinsky, D. J.; Naka, Y.; Liao, H.; Oz, M. C.; Wagner, D. D.; Mayadas, T. N.; Johnson, R. C.; Hynes, R. O.; Heath, M.; Lawson, C. A.; Stern, D. M.
    J Clin Invest, Volume: 97, Pages: 493-500 (1996) [PubMed]
  • Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice
    Mayadas, T. N.; Mendrick, D. L.; Brady, H. R.; Tang, T.; Papayianni, A.; Assmann, K. J.; Wagner, D. D.; Hynes, R. O.; Cotran, R. S.
    Kidney Int, Volume: 49, Pages: 1342-9 (1996) [PubMed]
  • Adhesion molecules--Part 1
    Frenette, P. S.; Wagner, D. D.
    N Engl J Med, Volume: 334, Pages: 1526-9 (1996) [PubMed]
  • Genetic manipulation of vascular adhesion molecules in mice
    Hynes, R. O.; Wagner, D. D.
    J Clin Invest, Volume: 98, Pages: 2193-5 (1996) [PubMed]
  • Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins
    Frenette, P. S.; Mayadas, T. N.; Rayburn, H.; Hynes, R. O.; Wagner, D. D.
    Cell, Volume: 84, Pages: 563-74 (1996) [PubMed]
  • Adhesion molecules--Part II: Blood vessels and blood cells
    Frenette, P. S.; Wagner, D. D.
    N Engl J Med, Volume: 335, Pages: 43-5 (1996) [PubMed]
  • Double knockout highlights value of endothelial selectins
    Frenette, P. S.; Mayadas, T. N.; Rayburn, H.; Hynes, R. O.; Wagner, D. D.
    Immunol Today, Volume: 17, Pages: 205 (1996) [PubMed]
1995
  • Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin
    Yamada, S.; Mayadas, T. N.; Yuan, F.; Wagner, D. D.; Hynes, R. O.; Melder, R. J.; Jain, R. K.
    Blood, Volume: 86, Pages: 3487-92 (1995) [PubMed]
  • Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin
    Frenette, P. S.; Johnson, R. C.; Hynes, R. O.; Wagner, D. D.
    Proc Natl Acad Sci U S A, Volume: 92, Pages: 7450-4 (1995) [PubMed]
  • Blood cell dynamics in P-selectin-deficient mice
    Johnson, R. C.; Mayadas, T. N.; Frenette, P. S.; Mebius, R. E.; Subramaniam, M.; Lacasce, A.; Hynes, R. O.; Wagner, D. D.
    Blood, Volume: 86, Pages: 1106-14 (1995) [PubMed]
  • P-selectin knockout: a mouse model for various human diseases
    Wagner, D. D.
    Ciba Found Symp, Volume: 189, Pages: 2-10; discussion 10-16, 77-8 (1995) [PubMed]
  • P-selectin chases a butterfly
    Wagner, D. D.
    J Clin Invest, Volume: 95, Pages: 1955-6 (1995) [PubMed]
  • Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice
    Subramaniam, M.; Saffaripour, S.; Watson, S. R.; Mayadas, T. N.; Hynes, R. O.; Wagner, D. D.
    J Exp Med, Volume: 181, Pages: 2277-82 (1995) [PubMed]
  • Structure, biology and genetics of von Willebrand factor.
    Wagner DD and Ginsburg D.
    In: Hematology: Basic Principles and Practices. 2nd Edition. Benz EJ, Cohen HJ, Furie B, Hoffman R and Shattil SJ. (Eds.). New York: Churchill Livingstone., Pages: 1717-1725 (1995)
  • Gene targeting of adhesion molecules in the vasculature.
    Wagner DD and Hynes RO.
    In: Series: Molecular genetics and gene therapy of cardiovascular diseases. Mockrin SC (Ed.) New York: Marcel Dekker., Pages: 403-405 (1995)
  • P-selectin-deficient mice: A model to study inflammation and metastasis.
    In: Series: Topics in Molecular Medicine Vol 1. Siess W, Lorenz R and Weber PC. (Eds.). New York: Raven Press., Pages: 105-116 (1995)
1994
  • von Willebrand factor proteolytic processing and multimerization precede the formation of Weibel-Palade bodies
    Vischer, U. M.; Wagner, D. D.
    Blood, Volume: 83, Pages: 3536-44 (1994) [PubMed]
1993
  • P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancer
    Stone, J. P.; Wagner, D. D.
    J Clin Invest, Volume: 92, Pages: 804-13 (1993) [PubMed]
  • Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
    Mayadas, T. N.; Johnson, R. C.; Rayburn, H.; Hynes, R. O.; Wagner, D. D.
    Cell, Volume: 74, Pages: 541-54 (1993) [PubMed]
  • Divergent fates of P- and E-selectins after their expression on the plasma membrane
    Subramaniam, M.; Koedam, J. A.; Wagner, D. D.
    Mol Biol Cell, Volume: 4, Pages: 791-801 (1993) [PubMed]
  • von Willebrand factor storage requires intact prosequence cleavage site
    Journet, A. M.; Saffaripour, S.; Cramer, E. M.; Tenza, D.; Wagner, D. D.
    Eur J Cell Biol, Volume: 60, Pages: 31-41 (1993) [PubMed]
  • CD63 is a component of Weibel-Palade bodies of human endothelial cells
    Vischer, U. M.; Wagner, D. D.
    Blood, Volume: 82, Pages: 1184-91 (1993) [PubMed]
  • The Weibel-Palade body: the storage granule for von Willebrand factor and P-selectin
    Wagner, D. D.
    Thromb Haemost, Volume: 70, Pages: 105-10 (1993) [PubMed]
  • Requirement for both D domains of the propolypeptide in von Willebrand factor multimerization and storage
    Journet, A. M.; Saffaripour, S.; Wagner, D. D.
    Thromb Haemost, Volume: 70, Pages: 1053-7 (1993) [PubMed]
1992
  • P-selectin, a granule membrane protein of platelets and endothelial cells, follows the regulated secretory pathway in AtT-20 cells
    Koedam, J. A.; Cramer, E. M.; Briend, E.; Furie, B.; Furie, B. C.; Wagner, D. D.
    J Cell Biol, Volume: 116, Pages: 617-25 (1992) [PubMed]
  • Vicinal cysteines in the prosequence play a role in von Willebrand factor multimer assembly
    Mayadas, T. N.; Wagner, D. D.
    Proc Natl Acad Sci U S A, Volume: 89, Pages: 3531-5 (1992) [PubMed]
  • A 130-kDa protein on endothelial cells binds to amino acids 15-42 of the B beta chain of fibrinogen
    Erban, J. K.; Wagner, D. D.
    J Biol Chem, Volume: 267, Pages: 2451-8 (1992) [PubMed]
  • P-selectin and E-selectin. Distinct but overlapping leukocyte ligand specificities
    Larsen, G. R.; Sako, D.; Ahern, T. J.; Shaffer, M.; Erban, J.; Sajer, S. A.; Gibson, R. M.; Wagner, D. D.; Furie, B. C.; Furie, B.
    J Biol Chem, Volume: 267, Pages: 11104-10 (1992) [PubMed]
1991
  • Induction of specific storage organelles by von Willebrand factor propolypeptide
    Wagner, D. D.; Saffaripour, S.; Bonfanti, R.; Sadler, J. E.; Cramer, E. M.; Chapman, B.; Mayadas, T. N.
    Cell, Volume: 64, Pages: 403-13 (1991) [PubMed]
  • PADGEM, a leukocyte receptor on activated platelets. Biology and application to in vivo medical diagnostics
    Furie, B.; Celi, A.; Palabrica, T. M.; Larsen, E.; Wagner, D. D.; Furie, B. C.
    Curr Stud Hematol Blood Transfus, Pages: 32-6 (1991) [PubMed]
  • von Willebrand factor and the endothelium
    Wagner, D. D.; Bonfanti, R.
    Mayo Clin Proc, Volume: 66, Pages: 621-7 (1991) [PubMed]
  • von Willebrand factor biosynthesis and processing
    Mayadas, T. N.; Wagner, D. D.
    Ann N Y Acad Sci, Volume: 614, Pages: 153-66 (1991) [PubMed]
  • PADGEM a Leukocyte Receptor on Activated Platelets: Biology and application to in vivo medical diagnostics.
    Furie B, Celi A, Palabrica TM, Larsen E, Wagner DD and Furie, BC.
    In: Biotechnology of Plasma Proteins: Haemostasis, Thrombosis and Iron Proteins. Albertini A, L’Enfant CL, Mannucci PM, and Sixma JJ. (Eds). Basel: Karger., Pages: 32-36. (1991)
  • Selectins: A family of adhesion receptors. Letter to the Editor.
    Bevilacqua E, Butcher E, Furie B, Furie B, Gallatin M, Gimbrone M, Harlan J, Kishimoto K, Lasky L, McEver R, Paulson J, Rosen S, Seed B, Siegelman M, Springer T, Stoolman L, Tedder T, Varki A, Wagner D, Weissman I and Zimmerman G.
    Cell., Volume: 67., Pages: 233. (1991)
  • Structure and biology of von Willebrand factor.
    Wagner DD.
    In: Hematology: Basic Principles and Practices. Benz EJ, Cohen HJ, Furie B, Hoffman R and Shattil SJ. (Eds.). New York: Churchill Livingstone., Pages: 1354-1358. (1991)
1990
  • Human endothelial cells synthesize, process, and secrete fibronectin molecules bearing an alternatively spliced type III homology (ED1)
    Peters, J. H.; Sporn, L. A.; Ginsberg, M. H.; Wagner, D. D.
    Blood, Volume: 75, Pages: 1801-8 (1990) [PubMed]
  • Cell biology of von Willebrand factor
    Wagner, D. D.
    Annu Rev Cell Biol, Volume: 6, Pages: 217-46 (1990) [PubMed]
  • PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15)
    Larsen, E.; Palabrica, T.; Sajer, S.; Gilbert, G. E.; Wagner, D. D.; Furie, B. C.; Furie, B.
    Cell, Volume: 63, Pages: 467-74 (1990) [PubMed]
1989
  • In vitro multimerization of von Willebrand factor is triggered by low pH. Importance of the propolypeptide and free sulfhydryls
    Mayadas, T. N.; Wagner, D. D.
    J Biol Chem, Volume: 264, Pages: 13497-503 (1989) [PubMed]
  • PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes
    Larsen, E.; Celi, A.; Gilbert, G. E.; Furie, B. C.; Erban, J. K.; Bonfanti, R.; Wagner, D. D.; Furie, B.
    Cell, Volume: 59, Pages: 305-12 (1989) [PubMed]
  • von Willebrand factor biosynthesis and partitioning between constitutive and regulated pathways of secretion after thrombin stimulation
    Mayadas, T.; Wagner, D. D.; Simpson, P. J.
    Blood, Volume: 73, Pages: 706-11 (1989) [PubMed]
  • Molecular and cellular biology of von Willebrand factor
    Handin, R. I.; Wagner, D. D.
    Prog Hemost Thromb, Volume: 9, Pages: 233-59 (1989) [PubMed]
  • PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells
    Bonfanti, R.; Furie, B. C.; Furie, B.; Wagner, D. D.
    Blood, Volume: 73, Pages: 1109-12 (1989) [PubMed]
  • Differing polarity of the constitutive and regulated secretory pathways for von Willebrand factor in endothelial cells
    Sporn, L. A.; Marder, V. J.; Wagner, D. D.
    J Cell Biol, Volume: 108, Pages: 1283-9 (1989) [PubMed]
  • Plasma selenium-dependent glutathione peroxidase. Cell of origin and secretion
    Avissar, N.; Whitin, J. C.; Allen, P. Z.; Wagner, D. D.; Liegey, P.; Cohen, H. J.
    J Biol Chem, Volume: 264, Pages: 15850-5 (1989) [PubMed]
  • Mediation of fibrin-induced release of von Willebrand factor from cultured endothelial cells by the fibrin beta chain
    Ribes, J. A.; Ni, F.; Wagner, D. D.; Francis, C. W.
    J Clin Invest, Volume: 84, Pages: 435-42 (1989) [PubMed]
  • Temperature-sensitive steps in the secretory pathway for von Willebrand factor in endothelial cells
    Roarke, M. C.; Wagner, D. D.; Marder, V. J.; Sporn, L. A.
    Eur J Cell Biol, Volume: 48, Pages: 337-43 (1989) [PubMed]
  • Storage and secretion of von Willebrand factor.
    Wagner DD.
    In: Role of Factor VIII and von Willebrand Factor. Zimmerman TS and Ruggeri ZM. (Eds.). New York: Marcel Dekker., Pages: 161-180. (1989)
1987
  • Topology and order of formation of interchain disulfide bonds in von Willebrand factor
    Wagner, D. D.; Lawrence, S. O.; Ohlsson-Wilhelm, B. M.; Fay, P. J.; Marder, V. J.
    Blood, Volume: 69, Pages: 27-32 (1987) [PubMed]
  • Divergent fates of von Willebrand factor and its propolypeptide (von Willebrand antigen II) after secretion from endothelial cells
    Wagner, D. D.; Fay, P. J.; Sporn, L. A.; Sinha, S.; Lawrence, S. O.; Marder, V. J.
    Proc Natl Acad Sci U S A, Volume: 84, Pages: 1955-9 (1987) [PubMed]
  • Intact microtubules are necessary for complete processing, storage and regulated secretion of von Willebrand factor by endothelial cells
    Sinha, S.; Wagner, D. D.
    Eur J Cell Biol, Volume: 43, Pages: 377-83 (1987) [PubMed]
  • von Willebrand factor released from Weibel-Palade bodies binds more avidly to extracellular matrix than that secreted constitutively
    Sporn, L. A.; Marder, V. J.; Wagner, D. D.
    Blood, Volume: 69, Pages: 1531-4 (1987) [PubMed]
  • Fibrin induces release of von Willebrand factor from endothelial cells
    Ribes, J. A.; Francis, C. W.; Wagner, D. D.
    J Clin Invest, Volume: 79, Pages: 117-23 (1987) [PubMed]
1986
  • Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II
    Fay, P. J.; Kawai, Y.; Wagner, D. D.; Ginsburg, D.; Bonthron, D.; Ohlsson-Wilhelm, B. M.; Chavin, S. I.; Abraham, G. N.; Handin, R. I.; Orkin, S. H.; et al.,
    Science, Volume: 232, Pages: 995-8 (1986) [PubMed]
  • Inducible secretion of large, biologically potent von Willebrand factor multimers
    Sporn, L. A.; Marder, V. J.; Wagner, D. D.
    Cell, Volume: 46, Pages: 185-90 (1986) [PubMed]
  • Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor
    Wagner, D. D.; Mayadas, T.; Marder, V. J.
    J Cell Biol, Volume: 102, Pages: 1320-4 (1986) [PubMed]
1985
  • Biosynthesis of von Willebrand protein by human megakaryocytes
    Sporn, L. A.; Chavin, S. I.; Marder, V. J.; Wagner, D. D.
    J Clin Invest, Volume: 76, Pages: 1102-6 (1985) [PubMed]
  • Inhibition of disulfide bonding of von Willebrand protein by monensin results in small, functionally defective multimers
    Wagner, D. D.; Mayadas, T.; Urban-Pickering, M.; Lewis, B. H.; Marder, V. J.
    J Cell Biol, Volume: 101, Pages: 112-20 (1985) [PubMed]
1984
  • Von Willebrand protein binds to extracellular matrices independently of collagen
    Wagner, D. D.; Urban-Pickering, M.; Marder, V. J.
    Proc Natl Acad Sci U S A, Volume: 81, Pages: 471-5 (1984) [PubMed]
  • Irradiation induces release of von Willebrand protein from endothelial cells in culture
    Sporn, L. A.; Rubin, P.; Marder, V. J.; Wagner, D. D.
    Blood, Volume: 64, Pages: 567-70 (1984) [PubMed]
  • Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization
    Wagner, D. D.; Marder, V. J.
    J Cell Biol, Volume: 99, Pages: 2123-30 (1984) [PubMed]
1983
  • Biosynthesis of von Willebrand protein by human endothelial cells. Identification of a large precursor polypeptide chain
    Wagner, D. D.; Marder, V. J.
    J Biol Chem, Volume: 258, Pages: 2065-7 (1983) [PubMed]
1982
  • Relationships between microfilaments, cell-substratum adhesion, and fibronectin
    Hynes, R. O.; Destree, A. T.; Wagner, D. D.
    Cold Spring Harb Symp Quant Biol, Volume: 46 Pt 2, Pages: 659-70 (1982) [PubMed]
  • Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells
    Wagner, D. D.; Olmsted, J. B.; Marder, V. J.
    J Cell Biol, Volume: 95, Pages: 355-60 (1982) [PubMed]
  • Fibronectin-coated beads are endocytosed by cells and align with microfilament bundles
    Wagner, D. D.; Hynes, R. O.
    Exp Cell Res, Volume: 140, Pages: 373-81 (1982) [PubMed]
  • Fibronectin dependent endocytosis by macrophage like (P388D1) and fibroblastic (NIL 8) cells.
    Van De Water L III, Wagner DD, Crenshaw EB III and Hynes RO.
    In: Cellular Recognition. Glaser L, Frazier W and Gottlieb D (Eds.). New York: Alan R. Liss., Pages: 869-878 (1982)
1981
  • Similarities and differences between the fibronectins of normal and transformed hamster cells
    Wagner, D. D.; Ivatt, R.; Destree, A. T.; Hynes, R. O.
    J Biol Chem, Volume: 256, Pages: 11708-15 (1981) [PubMed]
1980
  • Topological arrangement of the major structural features of fibronectin
    Wagner, D. D.; Hynes, R. O.
    J Biol Chem, Volume: 255, Pages: 4304-12 (1980) [PubMed]
1979
  • Cell surface fibronectin and oncogenic transformation
    Hynes, R. O.; Destree, A. T.; Perkins, M. E.; Wagner, D. D.
    J Supramol Struct, Volume: 11, Pages: 95-104 (1979) [PubMed]
  • Domain structure of fibronectin and its relation to function. Disulfides and sulfhydryl groups
    Wagner, D. D.; Hynes, R. O.
    J Biol Chem, Volume: 254, Pages: 6746-54 (1979) [PubMed]
1978
  • A large glycoprotein lost from the surfaces of transformed cells
    Hynes, R. O.; Ali, I. U.; Destree, A. T.; Mautner, V.; Perkins, M. E.; Senger, D. R.; Wagner, D. D.; Smith, K. K.
    Ann N Y Acad Sci, Volume: 312, Pages: 317-42 (1978) [PubMed]​