Publications
For more information about Denisa Wagner, please see her profile in Circulation Research, Leaders in Cardiovascular Science: www.ahajournals.org.
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Click HERE to visit Denisa's PubMed.
2024
  • Reflections on Targeting Neutrophil Extracellular Traps in Deep Vein Thrombosis. Martinod K, Wagner DD. Arterioscler Thromb Vasc Biol. 2024 Aug;44(8):1719-1724. doi: 10.1161/ATVBAHA.124.320148. Epub 2024 Jul 24. PubMed PMID: 39047082; PubMed Central PMCID: PMC11279430. [Pub Med]
  • Neutrophil NLRP3 promotes cardiac injury following acute myocardial infarction through IL-1β production, VWF release and NET deposition in the myocardium. Heger L, Schommer N, Van Bruggen S, Sheehy CE, Chan W, Wagner DD. Scientific Reports. In press, accepted 12 June 2024. doi:10.1038/s41598-024-64710-4 PMCID: PMC11196583 [Pub Med]
  • Neutrophil peptidylarginine deiminase 4 plays a systemic role in obesity-induced chronic inflammation in mice. Van Bruggen S, Sheehy C, Kraisin S, Frederix L, Wagner DD, Martinod, K. J Thromb Haemost. 2024 Feb 5;. doi: 10.1016/j.jtha.2024.01.022 [Epub ahead of print] PubMed PMID: 38325598. [Pub Med]
2023
  • Inhibition of protein arginine deiminase 4 prevents inflammation-mediated heart failure in arthritis. Heger LA, Schommer N, Fukui S, Van Bruggen S, Sheehy CE, Chu L, Rajagopal S, Sivanandhan D, Ewenstein B, Wagner DD. Life Sci Alliance. 2023 Oct;6(10). doi: 10.26508/lsa.202302055. Print 2023 Oct. PubMed PMID: 37500179; PubMed Central PMCID: PMC10374941. [Pub Med]
  • NLRP3 is essential for neutrophil polarization and chemotaxis in response to leukotriene B4 gradient. Van Bruggen S, Jarrot PA, Thomas E, Sheehy CE, Silva CMS, Hsu AY, Cunin P, Nigrovic PA, Gomes ER, Luo HR, Waterman CM, Wagner DD. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2303814120. doi: 10.1073/pnas.2303814120. Epub 2023 Aug 21. PubMed PMID: 37603754; PubMed Central PMCID: PMC10468616. [Pub Med]
  • Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4. Gajendran C, Fukui S, Sadhu NM, Zainuddin M, Rajagopal S, Gosu R, Gutch S, Fukui S, Sheehy CE, Chu L, Vishwakarma S, Jeyaraj DA, Hallur G, Wagner DD, Sivanandhan D. Sci Rep. 2023 Feb 23;13(1):3189. doi: 10.1038/s41598-023-30246-2. PubMed PMID: 36823444; PubMed Central PMCID: PMC9950073.[Pub Med]
2022
  • NLRP3 inflammasome activation in neutrophils directs early inflammatory response in murine peritonitis.
    Fukui S, Fukui S, Van Bruggen S, Shi L, Sheehy CE, Chu L, Wagner DD.  Sci Rep. 2022 Dec 9;12(1):21313. doi: 10.1038/s41598-022-25176-4. PubMed PMID: 36494392; PubMed Central PMCID: PMC9734191. [Pub Med]
  • Anti-inflammatory protective effect of ADAMTS-13 in murine arthritis models. Fukui S, Gutch S, Fukui S, Chu L, Wagner DD.  J Thromb Haemost. 2022 Jul 25. doi: 10.1111/jth.15828. Epub ahead of print. PMID: 35875933.[Pub Med]
  • Thromboinflammation: From Atherosclerosis to COVID-19. Wagner DD, Heger LA. Arterioscler Thromb Vasc Biol. 2022 Jul 8:101161ATVBAHA122317162. doi: 10.1161/ATVBAHA.122.317162. Epub ahead of print. PMID: 35861953. [Pub Med]
  • Neutrophil phenotypes and functions in cancer: A consensus statement. Quail DF, Amulic B, Aziz M, Barnes BJ, Eruslanov E, Fridlender ZG, Goodridge HS, Granot Z, Hidalgo A, Huttenlocher A, Kaplan MJ, Malanchi I, Merghoub T, Meylan E, Mittal V, Pittet MJ, Rubio-Ponce A, Udalova IA, van den Berg TK, Wagner DD, Wang P, Zychlinsky A, de Visser KE, Egeblad M, Kubes P.  J Exp Med. 2022 Jun 6;219(6):e20220011. doi: 10.1084/jem.20220011. Epub 2022 May 6. PMID: 35522219. [Pub Med]
  • The prominent role of hematopoietic peptidyl arginine deiminase 4 in arthritis: collagen and G-CSF induced arthritis model in C57BL/6 mice.  Fukui S, Gutch S, Fukui S, Cherpokova D, Aymonnier K, Sheehy CE, Chu L, Wagner DD. Arthritis Rheumatol. 2022 Feb 15. doi: 10.1002/art.42093. Epub ahead of print. PMID: 35166055. [Pub Med]
  • Inflammasome activation in neutrophils of patients with severe COVID-19. Aymonnier K, Ng J, Fredenburgh LE, Zambrano-Vera K, Münzer P, Gutch S, Fukui S, Desjardins M, Subramaniam M, Baron R, Raby BA, Perrella MA, Lederer JA, Wagner DD.  Blood Adv. 2022 Jan 6:bloodadvances.2021005949. doi: 10.1182/bloodadvances.2021005949. Epub ahead of print. PMID: 34991159; PMCID: PMC8741335. [Pub Med]

2021
  • Paul S. Frenette (1965-2021). Bowman TV, Jamieson C, Steidl U, Stanley ER, Gritsman K, Wagner D, Manwani D, Trumpp A, Suda T, Ito K, Dawlaty M, Lucas D, Pinho S.Cell. 2021 Sep 30;184(20):5073-5076. doi: 10.1016/j.cell.2021.08.034. [PubMed]
  • The role of SERPIN citrullination in thrombosis. Tilvawala R, Nemmara VV, Reyes AC, Sorvillo N, Salinger AJ, Cherpokova D, Fukui S, Gutch S, Wagner D, Thompson PR.Cell Chem Biol. 2021 Jul 27:S2451-9456(21)00349-4. doi: 10.1016/j.chembiol.2021.07.009. Online ahead of print. [PubMed]
  • Citrullinated Fibrinogen Renders Clots Mechanically Less Stable, but Lysis-Resistant. Varjú I, Sorvillo N, Cherpokova D, Farkas ÁZ, Farkas VJ, Komorowicz E, Feller T, Kiss B, Kellermayer MZ, Szabó L, Wacha A, Bóta A, Longstaff C, Wagner DD, Kolev K.Circ Res. 2021 Jul 9;129(2):342-344. doi: 10.1161/CIRCRESAHA.121.319061. Epub 2021 May 26. [PubMed]
  • The role of platelets in thrombus fibrosis and vessel wall remodeling after venous thrombosis. DeRoo E, Martinod K, Cherpokova D, Fuchs T, Cifuni S, Chu L, Staudinger C, Wagner DD. J Thromb Haemost. 2021 Feb;19(2):387-399. doi: 10.1111/jth.15134. Epub 2020 Nov 29. [PubMed]
  • NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions. Münzer P, Negro R, Fukui S, di Meglio L, Aymonnier K, Chu L, Cherpokova D, Gutch S, Sorvillo N, Shi L, Magupalli VG, Weber ANR, Scharf RE, Waterman CM, Wu H, Wagner DD. Front Immunol. 2021 May 28;12:683803. doi: 10.3389/fimmu.2021.683803. eCollection 2021. [PubMed]
  • Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4. Shi L, Aymonnier K, Wagner DD. PLoS One. 2021 May 17;16(5):e0251726. doi: 10.1371/journal.pone.0251726. eCollection 2021. [PubMed]

2020
  • Netosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture. Thiam HR, Wong SL, Qiu R, Kittisopikul M, Vahabikashi A, Goldman AE, Goldman RD, Wagner DD, Waterman CM.Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7326-7337. doi: 10.1073/pnas.1909546117. Epub 2020 Mar 13. [PubMed]
  • Recombinant human ADAMTS13 treatment and anti-NET strategies enhance skin allograft survival in mice. Wong SL, Goverman J, Staudinger C, Wagner DD. Am J Transplant. 2020 Apr;20(4):1162-1169. [PubMed]
  • Cellular Mechanisms of NETosis. Thiam HR, Wong SL, Wagner DD, Waterman CM.Annu Rev Cell Dev Biol. 2020 Oct 6;36:191-218. doi: 10.1146/annurev-cellbio-020520-111016. Epub 2020 Jul 14. [PubMed]
  • Reply to Liu: The disassembly of the actin cytoskeleton is an early event during NETosis. Thiam HR*, Wong SL*, Qiu R, Kittisopikul M, Vahabikashi A, Goldman AE, Goldman RD, Wagner DD*, Waterman CM*. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22655-22656. doi: 10.1073/pnas.2015951117. [PubMed] *equal contributors
2019
  • Plasma peptidylarginine deiminase IV promotes VWF-platelet string formation and accelerates thrombosis after vessel injury. Sorvillo N, Mizurini D, Coxon C, Martinod K, Tilvawala R, Cherpokova D, Salinger AJ, Seward RJ, Staudinger C, Weerapana E, Shapiro NI, Costello CE, Thompson PR, Wagner DD.  Circ Res. 2019 Aug 16;125(5):507-519. [PubMed]
  • Extracellular DNA NET-works with dire consequences for health. Sorvillo N, Cherpokova D, Martinod K, Wagner DD. Circ Res. 2019 Aug 2;125(4): 470-488.
  • Resolvin D4 attenuates the severity of pathological thrombosis in mice. Cherpokova D, Jouvene CC, Libreros S, DeRoo E, Chu L, de la Rosa X, Norris P, Wagner DD, Serhan CN. Blood. 2019 Oct 24;134(17):1458-1468. [PubMed]
2018
  • Solid peripheral tumor leads to systemic inflammation, astrocyte activation and signs of behavioral despair in mice. Demers M, Suidan GL, Andrews N, Martinod K, Cabral JE, Wagner DD. PLoS One. 2018 Nov 15;13(11):e0207241. [PubMed]
  • Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms. Wolach O, Sellar RS, Martinod K, Cherpokova D, McConkey M, Chappell RJ, Silver AJ, Adams D, Castellano CA, Schneider RK, Padera RF, DeAngelo DJ, Wadleigh M, Steensma DP, Galinsky I, Stone RM, Genovese G, McCarroll SA, Iliadou B, Hultman C, Neuberg D, Mullally A,  Wagner DD , Ebert BL. Sci Transl Med. 2018 Apr 11;10(436). [PubMed]
  • Roles of PAD4 and NETosis in experimental atherosclerosis and arterial injury: Implications for superficial erosion. Franck G, Mawson TL, Folco EJ, Ruvkun V, Engelbertsen D, Liu X, Tesmenitsky Y, Shvartz E, Wang Y, Sukhova G, Lichtman AH, Wagner DD, Nicoletti A, Croce K, Libby P. Circ Res. 2018 June 22;123(1):33-42. [PubMed]
  • Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD; National Heart, Lung, and Blood Institute Severe Asthma Research Program-3 Investigators. Sci Immunol. (2018) Volume: 3;3(26). [PubMed]
  • Peptidylarginine deiminase 4: a nuclear button triggering neutrophil extracellular traps in inflammatory diseases and aging. Wong SL, Wagner DD. FASEB J. (2018) Volume: 20. [PubMed]
  • Citrullnated histone H3, a biomarker of neutrophil extracellular trap formation, predicts the risk of venous thromboembolism in cancer patients. Mauracher LM, Posch F, Martinod K, Grilz E, Däullary T, Hell L, Brostjan C, Zielinski C, Ay C, Wagner DD, Pabinger I, Thaler J. JTH 2018. Volume:16. Pages:1- 11. [PubMed]
  • Recombinant Human RhADAMTS13 treatment improves myocardial remodeling and functionality after pressure overload injury in mice. Witsch T, Martinod K, Sorvillo N, Portier I, De Meyer S, Wagner DD. JAHA. Volume: 24; 7(3). [PubMed]
  • A key role for Rac and Pak in Neutrophil Extracellular Traps (NETs) formation defines a new potential therapeutic target. Gavillet, M, Martinod K, Renella R, Wagner DD, Williams D. AJH. Volume: 93(2), Pages: 269-276. [PubMed]​
2017
  • Peptidylarginine deiminase 4 promotes age-related organ fibrosis. Martinod K, Witsch T, Erpenbeck L, Savchenko A, Hayashi H, Cherpokova D, Gallant M, Mauler M, Cifuni SM, Wagner DD. J. Exp. Med. Volume: 214 (2), Pages: 439-458 (2017) Click here for PDF
  • ADAMTS13 deficiency worsens colitis and exogenous ADAMTS13 administration decreases colitis severity in mice. Zitomersky NL, Demers M, Martinod K, Gallant M, Cifuni SM, Biswas A, Snapper S, Wagner DD. TH Open. Volume: 1(1), Pages: c11-c23 (2017)  [PubMed]
  • Unraveling Vascular Inflammation: From Immunology to Imaging. Teague H, Ahlman M, Alavi A, Wagner DD, Lichtman AH, Nahrendorf M, Swirski F, Nestle F, Gelfand J, Kaplan M, Grinspoon S, Ridker P, Newby D, Tawakol A, Fayad Z, Mehta N. JACC. Volume: 70 (11), Pages: 1403-1412 (2017) [PubMed]
  • Mast cells granular contents are crucial for deep vein thrombosis in mice. Ponomaryov T, Payne H, Fabritz L, Wagner DD, Brill A. Circulation Research. Volume 121 (8), Pages: 941-950 (2017) [PubMed]    
  • Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice. Hayashi H, Cherpokova D, Martinod K, Witsch T, Wong SL, Gallant M, Cifuni SM, Guarente LP, Wagner DD. PLoS One. Volume: 12 (12) (2017) [PubMed]
2016
  • PAD4 deficiency decreases inflammation and susceptibility to pregnancy loss in a mouse model. Erpenbeck L, Chowdhury C, Zsengelle ZK, Gallant M, Burke SD, Cifuni S, Hahn S, Wagner DD, Karumanchi A. Biology of Reproduction. Volume: 95 (6), Pages:0, 1-11 (2016) [PubMed]
  • Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice. Shaw MA, Kombrinck KW, McElhinney KE, Sweet DR, Flick MJ, Palumbo JS, Cheng M, Esmon NL, Esmon CT, Brill A, Wagner DD, Degen JL, Mullins ES. Blood. Volume: 128 (5), Pages: 721-31 (2016) [PubMed]
  • Priming of neutrophils toward NETosis promotes tumor growth. Demers M, Wong SL, Martinod K, Gallant M, Cabral JE, Wang Y, Wagner DD.  Oncoimmunology. Volume: 5 (5) (2016) [PubMed]
  • Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M, Homer RJ, Flavell RA, Wagner DD, Montgomery RR, Shaw AC, Staeheli P, Iwasaki A. Science. Volume: 352(6284), Pages: 463-6 (2016) [PubMed]
  • OC-16 - Neutrophil extracellular traps and tissue factor-bearing microvesicles: a liaison dangereuse causing overt DIC in cancer patients? Hell L, Thaler J, Martinod K, Ay C, Posch F, Wagner DD, Pabinger I. Thromb Res. (2016) [PubMed]
  • NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation.  Thålin C, Demers M, Blomgren B, Wong SL, von Arbin M, von Heijne A, Laska AC, Wallén H, Wagner DD, Aspberg S.  Thromb Res. Volume: 139, Pages: 56-64 [PubMed]
  • Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis. Martinod K, Witsch T, Farley K, Gallant M, Remold-O'Donnell E, Wagner DD.  J Thromb Haemost. Volume: 14(3), Pages:551-8 (2016) [PubMed]
  • ADAMTS13 Endopeptidase Protects against Vascular Endothelial Growth Factor Inhibitor-Induced Thrombotic Microangiopathy. Erpenbeck L, Demers M, Zsengellér ZK, Gallant M, Cifuni SM, Stillman IE, Karumanchi SA, Wagner DD.  J Am Soc Nephrol. Volume: 27(1), Pages:120-31 (2016) [PubMed]

2015 
  • Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples. Gavillet M, Martinod K, Renella R, Harris C, Shapiro NI, Wagner DD, Williams DA. Am J Hematol. Volume: 90(12), Pages:1155-8 (2016) [PubMed]
  • Diabetes primes neutrophils to undergo NETosis which severely impairs wound healing. Wong SL, Martinod K, Demers M, Gallant M, Wang Y, Kahn CR, Wagner DD. Nature Medicine (2015) [PubMed]
  • Dietary Omega-3 Alpha-Linolenic Acid does not prevent venous thrombosis in mice. Reiner MF, Martinod K, Stivala S, Camici GC, Luscher TF, Wagner DD, Beer JH. Thrombosis and haemostasis., Volume: 113, Pages: 177-84 (2015) [PubMed]
  • Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung C, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, David M. Wilson DM
    Nature Chemical Biology, Volume: 11, Pages: 189-9 (2015) [PubMed]
  • PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock. Martinod K, Fuchs Ta, Zitomersky NL, Wong SL, Demers M, Gallant M Wang Y, Wagner DD. Blood, Volume: 19, Pages: 1948-56 (2015) [PubMed]
  • P-selectin promotes neutrophil extracellular trap formation in mice. Etulain J, Martinod K, Wong SL, Cifuni SM, Schattner M, Wagner DD. Blood, Volume: 9, Pages: 242-6 (2015) [PubMed]
  • Tissue factor expressed by circulating cancer cell-derived microparticles drastically increases the incidence of deep vein thrombosis in mice. Thomas GM, Brill A, Mezouar L, Crescence L, Gallant M, Dubois C, Wagner DD. Journal of Thrombosis and Haemostasis, Volume: 13, Pages: 1310-9 (2015) [PubMed]
2014
  • VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice. Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD. Blood, Volume: 123, Pages: 141-148 (2014) [PubMed]
  • Thrombosis: Tangled up in NETs. Martinod K, Wagner DD. Blood, Volume: 123, Pages: 2768-2776 (2014) [PubMed]
  • NETosis: a new factor in tumor progression and cancer-associated thrombosis. Demers M, Wagner DD. Semin Thromb Hemost, Volume: 40, Pages: 277-283 (2014) [PubMed]
  • Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development. Savchenko AS, Martinod K, Seidman MA, Wong SL, Borissoff JI, Piazza G, Libby P, Goldhaber SZ, Mitchell RN, Wagner DD. J Thromb Haemost, Volume: 12, Pages: 860-70 (2014) [PubMed]
  • Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease. Chen G, Zhang D, Fuchs TA, Manwani D, Wagner DD, Frenette PS. Blood, Volume: 123, Pages: 3818-27 (2014) [PubMed]
2013
  • Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice. Duerschmied D, Suidan GL, Demers M, Herr N, Carbo C, Brill A, Cifuni SM, Mauler M, Cicko S, Bader M, Idzko M, Bode C, Wagner DD. Blood, Volume: 121, Pages: 1008-15 (2013) [PubMed]
  • Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. Carbo C, Yuki K, Demers M, Wagner DD, Shimaoka M. J Anesth, Volume: 27, Pages: 261-268 (2013) [PubMed]
  • Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities. Suidan GL, Duerschmied D, Dillon GM, Vanderhorst V, Hampton TG, Wong SL, Voorhees JR, Wagner DD. PLoS One, Volume: 8, Pages: e59032 (2013) [PubMed]
  • Neutrophil extracellular traps: A new link to cancer-associated thrombosis and potential implications for tumor progression. Demers M, Wagner DD.
    Oncoimmunology, Volume: 2, Pages: e22946 (2013) [PubMed]
  • Plasma DNA is elevated in patients with deep vein thrombosis. Diaz JA, Fuchs TA, Jackson TO, Hovinga JA, Lämmle B, Henke PK, Myers DD Jr, Wagner DD, Wakefield TW; for the Michigan Research Venous Group. J Vasc Surg, Volume: 1 (2013) [PubMed]
  • Neutrophils release extracellular DNA traps during storage of red blood cell units. Fuchs TA, Alvarez JJ, Martinod K, Bhandari AA, Kaufman RM, Wagner DD. Transfusion, Volume: 53, Pages: 3210-6 (2013) [PubMed]
  • Hypoxia, such as encountered at high altitude, promotes deep vein thrombosis in mice. Brill A, Suidan GL, Wagner DD. J Thromb Haemost, Volume: 11, Pages: 1773-5 (2013) [PubMed]
  • Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice. Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, Hu J, Wang Y, Wagner DD. Proc Natl Acad Sci U S A, Volume: 110, Pages: 8674-9 (2013) [PubMed]
  • Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state.
    Borissoff JI, Joosen IA, Versteylen MO, Brill A, Fuchs TA, Savchenko AS, Gallant M, Martinod K, Ten Cate H, Hofstra L, Crijns HJ, Wagner DD, Kietselaer BL.
    Arterioscler Thromb Vasc Biol, Volume: 33, Pages: 2032-2040 (2013) [PubMed]
  • Endothelial von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice. Suidan GL, Brill A, De Meyer SF, Voorhees JR, Cifuni SM, Cabral JE, Wagner DD. Arterioscler Thromb Vasc Biol, Volume: 33, Pages: 2112-20 (2013) [PubMed]
2012
  • Targeting platelet function to improve drug delivery. Demers M, Wagner DD. OncoImmunology, Volume: 1, Pages: 100-02 (2012) [PubMed]
  • von Willebrand factor: an emerging target in stroke therapy. De Meyer SF, Stoll G, Wagner DD, Kleinschnitz C. Stroke, Volume: 43, Pages: 599-606 (2012) [PubMed]
  • Desialylation accelerates platelet clearance following refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice. Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. Blood, Volume: 119, Pages: 1263-73 (2012) [PubMed]
  • Neutrophil extracellular traps promote deep vein thrombosis in mice. Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD. J Thromb Haemost, Volume: 10, Pages: 136-44 (2012) [PubMed]
  • ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion. Siller-Matula JM, Merhi Y, Tanguay JF, Duerschmied D, Wagner DD, McGinness KE, Pendergrast PS, Chung JK, Tian X, Schaub RG, Jilma B. Arterioscler Thromb Vasc Biol, Volume: 32, Pages: 902-9 (2012) [PubMed]
  • Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Köllnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, Manukyan D, Braun S, Lange P, Riegger J, Ware J, Eckart A, Haidari S, Rudelius M, Schulz C, Echtler K, Brinkmann V, Schwaiger M, Preissner KT, Wagner DD, Mackman N, Engelmann B, Massberg S. J Exp Med, Volume: 209, Pages: 819-35 (2012) [PubMed]
  • Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies. Fuchs TA, Kremer Hovinga JA, Schatzberg D, Wagner DD, Lämmle B. Blood, Volume: 120, Pages: 1157-64 (2012) [PubMed]
  • Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice. Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD. Blood, Volume: 119, Pages: 6335-43 (2012) [PubMed] Click here for PDF
  • Extracellular chromatin is an important mediator of ischemic stroke in mice. De Meyer SF, Suidan GL, Fuchs TA, Monestier M, Wagner DD. Volume: 32, Pages: 1884-91 (2012) [PubMed] Click here for PDF
  • Neutrophil extracellular trap (NET) impact on deep vein thrombosis. Fuchs TA, Brill A, Wagner DD. Arterioscler Thromb Vasc Biol, Volume: 32, Pages: 1777-83 (2012) [PubMed]
  • Extrahepatic high-density lipoprotein receptor SR-BI and apoA-I protect against deep vein thrombosis in mice. Brill A, Yesilaltay A, De Meyer SF, Kisucka J, Fuchs TA, Kocher O, Krieger M, Wagner DD. Arterioscler Thromb Vasc Biol, Volume: 32, Pages: 1841-7 (2012) [PubMed]
  • Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Korin N, Kanapathipillai M, Matthews BD, Crescente M, Brill A, Mammoto T, Ghosh K, Jurek S, Bencherif SA, Bhatta D, Coskun AU, Feldman CL, Wagner DD, Ingber DE. Science, Volume: 337, Pages: 738-42 (2012) [PubMed]
  • Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT, Wagner DD. Proc Natl Acad Sci U S A, Volume: 106, Pages: 13076-81 (2012) [PubMed] Click here for PDF
  • ADAMTS13 exerts a thrombolytic effect in microcirculation. Crescente M, Thomas GM, Demers M, Voorhees JR, Wong SL, Ho-Tin-Noé B, Wagner DD.
    Thromb Haemost, Volume: 108, Pages: 527-32 (2012) [PubMed]
  • Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice. De Meyer SF, Savchenko AS, Haas MS, Schatzberg D, Carroll MC, Schiviz A, Dietrich B, Rottensteiner H, Scheiflinger F, Wagner DD. Blood 2012 Dec 20;120(26):5217-23. , Volume: 120, Pages: 5217-23 (2012) [PubMed]
  • Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo. Chen K, Nishi H, Travers R, Tsuboi N, Martinod K, Wagner DD, Stan R, Croce K, Mayadas TN. Blood , Volume: 120, Pages: 4421-31 (2012) [PubMed]
2011
  • Increased efficacy of breast cancer chemotherapy in thrombocytopenic mice. Demers M, Ho-Tin-Noé B, Schatzberg D, Yang JJ, Wagner DD Cancer Res, Volume: 71 , Pages: 1540-9 (2011) [PubMed]
  • von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models. Brill A, Fuchs TA, Chauhan AK, Yang JJ, De Meyer SF, Köllnberger M, Wakefield TW, Lämmle B, Massberg S, Wagner DD. Blood., Volume: 117, Pages: 1400-7 (2011) [PubMed]
  • The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD and Degen JL. Blood., Volume: 117, Pages: 6326-6337 (2011) [PubMed]
  • Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling. Stadtmann A, Brinkhaus L, Mueller H, Rossaint J, Bolomini-Vittori M, Bergmeier W, Van Aken H, Wagner DD, Laudanna C, Ley K, Zarbock A. Eur J Immunol, Volume: 41, Pages: 2074-2085 (2011) [PubMed]
  • Histones induce rapid and profound thrombocytopenia in mice. Fuchs TA, Bhandari AA, Wagner DD. Blood, Volume: 118, Pages: 3708-3714 (2011) [PubMed]
  • How platelets safeguard vascular integrity. Ho-Tin-Noé B, Demers M, Wagner DD. J Thromb Haemost, Volume: 9 , Pages: 56-65 (2011) [PubMed]
  • Platelet glycoprotein Ibalpha is an important mediator of ischemic stroke in mice. De Meyer SF, Scwharz T, Schatzberg D, Wagner DD. Exp Transl Stroke Med, Volume: 3, Pages: 9 (2011) [PubMed]
2010
  • p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo.
    Canault M, Duerschmied D, Brill A, Stefanini L. Schatzberg D, Cifuni SM, Bergmeier, Wagner DD. Blood, Volume: 115, Pages: 1835-42 (2010) [PubMed]
  • Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis. Carbo C, Duerschmied D, Goerge T, Hattori H, Sakai J, Cifuni SM, White II GC, Chrzanowska-Wodnicka M, Luo HR, Wagner DD J Leukoc Biol, , Volume: 88, Pages: 313-19 (2010) [PubMed]
  • The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation. Canault M, Certel K, Schatzberg D, Wagner DD, Hynes RO. PLoS One. , Volume: 5, Pages: e13433 (2010) [PubMed]
  • A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH. J Exp Med, Volume: 207, Pages: 1967-79 (2010) [PubMed]
  • Extracellular DNA traps promote thrombosis. Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD Jr, Wrobleski SK, Wakefield TW, Hartwig JH, Wagner DD. Proc Natl Acad Sci U S A. , Volume: 107, Pages: 15880-5 (2010) [PubMed] Click here for PDF
2009
  • The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation. Banno F, Chauhan AK, Kokame K, Yang J, Miyata S, Wagner DD, and Miyata T. Blood, Volume: 113, Pages: 5323-5329 (2009) [PubMed]
  • Differential stimulation of monocytic cells results in distinct populations of microparticles. Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD. J Thromb Haemost, Volume: 7, Pages: 1019-1028 (2009) [PubMed]
  • Structure, biology and genetics of von Willebrand factor. Ginsburg D and Wagner DD. Structure, biology and genetics of von Willebrand factor.
    In: Hematology: Basic Principles and Practices. 5th Edition. Hoffman R, Benz EJ, Shattil SJ, Furie B, Silberstein LE, McGlave P, Heslop H. (Eds.). NY: Churchill Livingstone (2009)
  • Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis. Kisucka J, Chauhan AK, Zhao BQ, Patten IS, Yesilaltay A, Krieger M, Wagner DD. Blood, Volume: 113, Pages: 6015-6022 (2009) [PubMed]
  • Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779. Diener JL, Daniel Lagasse HA, Duerschmied D, Merhi Y, Tanguay JF, Hutabarat R, Gilbert J, Wagner DD, Schaub R. J Thromb Haemost, Volume: 7, Pages: 1155-1162 (2009) [PubMed]
  • Serotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17). Duerschmied D, Canault M, Lievens D, Brill A, Cifuni SM, Bader M, Wagner DD. J Thromb Haemost, Volume: 7, Pages: 1163-1171 (2009) [PubMed]
  • Platelets: guardians of tumor vasculature. Ho-Tin-Noe B, Goerge T, Wagner DD. Cancer Res, Volume: 69, Pages: 5623-5626 (2009) [PubMed]
  • Inhibition of VEGF or TGF-{beta} signaling activates endothelium and increases leukocyte rolling. Walshe TE, Dole VS, Maharaj AS, Patten IS, Wagner DD, D'Amore PA. Arterioscler Thromb Vasc Biol, Volume: 29, Pages: 1185-1192 (2009) [PubMed]
  • Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion. Brill A, Chauhan AK, Canault M, Walsh MT, Bergmeier W, Wagner DD. Cardiovasc Res, Volume: 84, Pages: 137-144 (2009) [PubMed]
  • Innate immune cells induce hemorrhage in tumors during thrombocytopenia. Ho-Tin-Noé B, Carbo C, Demers M, Cifuni SM, Goerge T, Wagner DD. Am J Path, Volume: 175, Pages: 1699-708 (2009) [PubMed]
  • von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke. Zhao BQ, Chauhan AK, Canault M, Patten IS, Yang JJ, Dockal M, Scheiflinger F, Wagner DD. Blood, Volume: 114, Pages: 3329-34 (2009) [PubMed]
2008
  • CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets. Cifuni, S. M.; Wagner, D. D.; Bergmeier, W. Blood, Volume: 112, Pages: 1696-703 (2008) [PubMed]
  • The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis Chauhan, A. K.; Walsh, M. T.; Zhu, G.; Ginsburg, D.; Wagner, D. D.; Motto, D. G. Blood, Volume: 111, Pages: 3452-7 (2008) [PubMed]
  • Prothrombotic effects of fibronectin isoforms containing the EDA domain. Chauhan, A. K.; Kisucka, J.; Cozzi, M. R.; Walsh, M. T.; Moretti, F. A.; Battiston, M.; Mazzucato, M.; De Marco, L.; Baralle, F. E.; Wagner, D. D.; Muro, A. F. Arterioscler Thromb Vasc Biol, Volume: 28, Pages: 296-301 (2008) [PubMed]
  • The effect of C1 inhibitor on intestinal ischemia and reperfusion injury. Lu, F.; Chauhan, A. K.; Fernandes, S. M.; Walsh, M. T.; Wagner, D. D.; Davis 3rd, A. E. Am J Physiol Gastrointest Liver Physiol (2008) [PubMed]
  • Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis. Kisucka, J.; Chauhan, A. K.; Patten, I. S.; Yesilaltay, A.; Neumann, C.; Van Etten, R. A.; Krieger, M.; Wagner, D. D. Circ Res, Volume: 103, Pages: 598-605 (2008) [PubMed]
  • Platelet granule secretion continuously prevents intratumor hemorrhageHo-Tin-Noe, B.; Goerge, T.; Cifuni, S. M.; Duerschmied, D.; Wagner, D. D.
    Cancer Res, Volume: 68, Pages: 6851-8 (2008) [PubMed]
  • Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice. Dole, V. S.; Matuskova, J.; Vasile, E.; Yesilaltay, A.; Bergmeier, W.; Bernimoulin, M.; Wagner, D. D.; Krieger, M. Arterioscler Thromb Vasc Biol, Volume: 28, Pages: 1111-6 (2008) [PubMed]
  • Glycoprotein Ibalpha and von Willebrand factor in primary platelet adhesion and thrombus formation: lessons from mutant mice. Bergmeier, W.; Chauhan, A. K.; Wagner, D. D. Thromb Haemost, Volume: 99, Pages: 264-70 (2008) [PubMed]
  • The vessel wall and its interactions. Wagner, D. D.; Frenette, P. S. Blood, Volume: 111, Pages: 5271-81 (2008) [PubMed]
  • Inflammation induces hemorrhage in thrombocytopenia. Goerge, T.; Ho-Tin-Noe, B.; Carbo, C.; Benarafa, C.; Remold-O'Donnell, E.; Zhao, B. Q.; Cifuni, S. M.; Wagner, D. D. Blood, Volume: 111, Pages: 4958-64 (2008) [PubMed]
  • von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis. Noubade, R.; del Rio, R.; McElvany, B.; Zachary, J. F.; Millward, J. M.; Wagner, D. D.; Offner, H.; Blankenhorn, E. P.; Teuscher, C. Am J Pathol, Volume: 173, Pages: 892-900 (2008) [PubMed]
  • ADAMTS13: a new link between thrombosis and inflammation. Chauhan, A. K.; Kisucka, J.; Brill, A.; Walsh, M. T.; Scheiflinger, F.; Wagner, D. D.
    J Exp Med, Volume: 205, Pages: 2065-74 (2008) [PubMed]
2007
  • Formation of platelet strings and microthrombi in the presence of ADAMTS-13 inhibitor does not require P-selectin or beta3 integrin. Chauhan, A. K.; Goerge, T.; Schneider, S. W.; Wagner, D. D. J Thromb Haemost, Volume: 5, Pages: 583-9 (2007) [PubMed]
  • Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Zhu, L.; Bergmeier, W.; Wu, J.; Jiang, H.; Stalker, T. J.; Cieslak, M.; Fan, R.; Boumsell, L.; Kumanogoh, A.; Kikutani, H.; Tamagnone, L.; Wagner, D. D.; Milla, M. E.; Brass, L. F. Proc Natl Acad Sci U S A, Volume: 104, Pages: 1621-6 (2007) [PubMed]
  • ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage. Hafezi-Moghadam, A.; Thomas, K. L.; Wagner, D. D. Am J Physiol Cell Physiol, Volume: 292, Pages: C1256-62 (2007) [PubMed]
  • Alteromonas tagae sp. nov. and Alteromonas simiduii sp. nov., mercury-resistant bacteria isolated from a Taiwanese estuary. Chiu, H. H.; Shieh, W. Y.; Lin, S. Y.; Tseng, C. M.; Chiang, P. W.; Wagner-Dobler, I. Int J Syst Evol Microbiol, Volume: 57, Pages: 1209-16 (2007) [PubMed]
  • von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins. Chauhan, A. K.; Kisucka, J.; Lamb, C. B.; Bergmeier, W.; Wagner, D. D. Blood, Volume: 109, Pages: 2424-9 (2007) [PubMed]
  • PSGL-1 regulates platelet P-selectin-mediated endothelial activation and shedding of P-selectin from activated platelets. Dole, V. S.; Bergmeier, W.; Patten, I. S.; Hirahashi, J.; Mayadas, T. N.; Wagner, D. D. Thromb Haemost, Volume: 98, Pages: 806-12 (2007) [PubMed]
  • Platelet adhesion receptors and their ligands in mouse models of thrombosis. Denis, C. V.; Wagner, D. D. Arterioscler Thromb Vasc Biol, Volume: 27, Pages: 728-39 (2007) [PubMed]
  • Dynamic visualization of thrombopoiesis within bone marrow. Junt, T.; Schulze, H.; Chen, Z.; Massberg, S.; Goerge, T.; Krueger, A.; Wagner, D. D.; Graf, T.; Italiano, J. E., Jr.; Shivdasani, R. A.; von Andrian, U. H. Science, Volume: 317, Pages: 1767-70 (2007) [PubMed]
  • Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III. Bergmeier, W.; Goerge, T.; Wang, H. W.; Crittenden, J. R.; Baldwin, A. C.; Cifuni, S. M.; Housman, D. E.; Graybiel, A. M.; Wagner, D. D. J Clin Invest, Volume: 117, Pages: 1699-707 (2007) [PubMed]
  • In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration. Babic, A. M.; Josefsson, E. C.; Bergmeier, W.; Wagner, D. D.; Kaufman, R. M.; Silberstein, L. E.; Stossel, T. P.; Hartwig, J. H.; Hoffmeister, K. M. Transfusion, Volume: 47, Pages: 442-51 (2007) [PubMed]
  • Platelet adhesion receptors do not modulate infarct volume after a photochemically induced stroke in mice. Frederix, K.; Chauhan, A. K.; Kisucka, J.; Zhao, B. Q.; Hoff, E. I.; Spronk, H. M.; Ten Cate, H.; Wagner, D. D. Brain Res, Volume: 1185, Pages: 239-45 (2007) [PubMed]
2006
  • Systemic antithrombotic effects of ADAMTS13. Chauhan, A. K.; Motto, D. G.; Lamb, C. B.; Bergmeier, W.; Dockal, M.; Plaimauer, B.; Scheiflinger, F.; Ginsburg, D.; Wagner, D. D. J Exp Med, Volume: 203, Pages: 767-76 (2006) [PubMed]
  • Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Hirahashi, J.; Mekala, D.; Van Ziffle, J.; Xiao, L.; Saffaripour, S.; Wagner, D. D.; Shapiro, S. D.; Lowell, C.; Mayadas, T. N. Immunity, Volume: 25, Pages: 271-83 (2006) [PubMed]
  • Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Kisucka, J.; Butterfield, C. E.; Duda, D. G.; Eichenberger, S. C.; Saffaripour, S.; Ware, J.; Ruggeri, Z. M.; Jain, R. K.; Folkman, J.; Wagner, D. D. Proc Natl Acad Sci U S A, Volume: 103, Pages: 855-60 (2006) [PubMed]
  • The A2B adenosine receptor protects against inflammation and excessive vascular adhesion. Yang, D.; Zhang, Y.; Nguyen, H. G.; Koupenova, M.; Chauhan, A. K.; Makitalo, M.; Jones, M. R.; St Hilaire, C.; Seldin, D. C.; Toselli, P.; Lamperti, E.; Schreiber, B. M.; Gavras, H.; Wagner, D. D.; Ravid, K. J Clin Invest, Volume: 116, Pages: 1913-23 (2006) [PubMed]
  • The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Bergmeier, W.; Piffath, C. L.; Goerge, T.; Cifuni, S. M.; Ruggeri, Z. M.; Ware, J.; Wagner, D. D. Proc Natl Acad Sci U S A, Volume: 103, Pages: 16900-5 (2006) [PubMed]
  • Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Kamath, A. F.; Chauhan, A. K.; Kisucka, J.; Dole, V. S.; Loscalzo, J.; Handy, D. E.; Wagner, D. D. Blood, Volume: 107, Pages: 591-3 (2006) [PubMed]
  • Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. Yang, H.; Reheman, A.; Chen, P.; Zhu, G.; Hynes, R. O.; Freedman, J.; Wagner, D. D.; Ni, H. J Thromb Haemost, Volume: 4, Pages: 2230-7 (2006) [PubMed]
  • Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles. Matuskova, J.; Chauhan, A. K.; Cambien, B.; Astrof, S.; Dole, V. S.; Piffath, C. L.; Hynes, R. O.; Wagner, D. D. Arterioscler Thromb Vasc Biol, Volume: 26, Pages: 1391-6 (2006) [PubMed]
  • Inflammation. Bergmeier W and Wagner DD. In: Platelets. 2nd Edition. Michelson A (Ed.) San Diego: Elsevier – Academic Press (2006)
2005
  • Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin. Dole, V. S.; Bergmeier, W.; Mitchell, H. A.; Eichenberger, S. C.; Wagner, D. D. Blood, Volume: 106, Pages: 2334-9 (2005) [PubMed]
  • Aspirin induces platelet receptor shedding via ADAM17 (TACE) Aktas, B.; Pozgajova, M.; Bergmeier, W.; Sunnarborg, S.; Offermanns, S.; Lee, D.; Wagner, D. D.; Nieswandt, B. J Biol Chem, Volume: 280, Pages: 39716-22 (2005) [PubMed]
  • The P-selectin, tissue factor, coagulation triad. Polgar, J.; Matuskova, J.; Wagner, D. D. J Thromb Haemost, Volume: 3, Pages: 1590-6 (2005) [PubMed]
  • A direct role for C1 inhibitor in regulation of leukocyte adhesion. Cai, S.; Dole, V. S.; Bergmeier, W.; Scafidi, J.; Feng, H.; Wagner, D. D.; Davis, A. E., 3rd
    J Immunol, Volume: 174, Pages: 6462-6 (2005) [PubMed]
  • New links between inflammation and thrombosis. Wagner, D. D. Arterioscler Thromb Vasc Biol, Volume: 25, Pages: 1321-4 (2005) [PubMed]
  • Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. Motto, D. G.; Chauhan, A. K.; Zhu, G.; Homeister, J.; Lamb, C. B.; Desch, K. C.; Zhang, W.; Tsai, H. M.; Wagner, D. D.; Ginsburg, D. J Clin Invest, Volume: 115, Pages: 2752-61 (2005) [PubMed]
  • Elevated soluble ICAM-1 levels induce immune deficiency and increase adiposity in mice. Wang, H. W.; Babic, A. M.; Mitchell, H. A.; Liu, K.; Wagner, D. D. FASEB J, Volume: 19, Pages: 1018-20 (2005) [PubMed]
2004
  • A new role in hemostasis for the adhesion receptor P-selectin. Cambien, B.; Wagner, D. D. Trends Mol Med, Volume: 10, Pages: 179-86 (2004) [PubMed]
  • ICAM-1 and beta2 integrin deficiency impairs fat oxidation and insulin metabolism during fasting. Babic, A. M.; Wang, H. W.; Lai, M. J.; Daniels, T. G.; Felbinger, T. W.; Burger, P. C.; Stricker-Krongrad, A.; Wagner, D. D. Mol Med, Volume: 10, Pages: 72-9 (2004) [PubMed]
  • CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Crittenden, J. R.; Bergmeier, W.; Zhang, Y.; Piffath, C. L.; Liang, Y.; Wagner, D. D.; Housman, D. E.; Graybiel, A. M. Nat Med, Volume: 10, Pages: 982-6 (2004) [PubMed]
  • Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier. Kondo, T.; Hafezi-Moghadam, A.; Thomas, K.; Wagner, D. D.; Kahn, C. R. Biochem Biophys Res Commun, Volume: 317, Pages: 315-20 (2004) [PubMed]
  • GPVI down-regulation in murine platelets through metalloproteinase-dependent shedding. Bergmeier, W.; Rabie, T.; Strehl, A.; Piffath, C. L.; Prostredna, M.; Wagner, D. D.; Nieswandt, B. Thromb Haemost, Volume: 91, Pages: 951-8 (2004) [PubMed]
  • Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo. Bergmeier, W.; Piffath, C. L.; Cheng, G.; Dole, V. S.; Zhang, Y.; von Andrian, U. H.; Wagner, D. D. Circ Res, Volume: 95, Pages: 677-83 (2004) [PubMed]
  • Structure, biology and genetics of von Willebrand factor. Ginsburg D and Wagner DD. In: Hematology: Basic Principles and Practices. 4th Edition. Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE and McGlave P. (Eds.). New York: Churchill Livingstone (2004)
2003
  • Antithrombotic activity of TNF-alpha. Cambien, B.; Bergmeier, W.; Saffaripour, S.; Mitchell, H. A.; Wagner, D. D. J Clin Invest, Volume: 112, Pages: 1589-96 (2003) [PubMed]
  • Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Matsushita, K.; Morrell, C. N.; Cambien, B.; Yang, S. X.; Yamakuchi, M.; Bao, C.; Hara, M. R.; Quick, R. A.; Cao, W.; O'Rourke, B.; Lowenstein, J. M.; Pevsner, J.; Wagner, D. D.; Lowenstein, C. J. Cell, Volume: 115, Pages: 139-50 (2003) [PubMed]
  • The clearance mechanism of chilled blood platelets. Hoffmeister, K. M.; Felbinger, T. W.; Falet, H.; Denis, C. V.; Bergmeier, W.; Mayadas, T. N.; von Andrian, U. H.; Wagner, D. D.; Stossel, T. P.; Hartwig, J. H. Cell, Volume: 112, Pages: 87-97 (2003) [PubMed]
  • Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Ni, H.; Yuen, P. S.; Papalia, J. M.; Trevithick, J. E.; Sakai, T.; Fassler, R.; Hynes, R. O.; Wagner, D. D. Proc Natl Acad Sci U S A, Volume: 100, Pages: 2415-9 (2003) [PubMed]
  • Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Hrachovinova, I.; Cambien, B.; Hafezi-Moghadam, A.; Kappelmayer, J.; Camphausen, R. T.; Widom, A.; Xia, L.; Kazazian, H. H., Jr.; Schaub, R. G.; McEver, R. P.; Wagner, D. D. Nat Med, Volume: 9, Pages: 1020-5 (2003) [PubMed]
  • P-selectin and leukocyte microparticles are associated with venous thrombogenesis Myers, D. D.; Hawley, A. E.; Farris, D. M.; Wrobleski, S. K.; Thanaporn, P.; Schaub, R. G.; Wagner, D. D.; Kumar, A.; Wakefield, T. W. J Vasc Surg, Volume: 38, Pages: 1075-89 (2003) [PubMed]
  • Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets. Bergmeier, W.; Burger, P. C.; Piffath, C. L.; Hoffmeister, K. M.; Hartwig, J. H.; Nieswandt, B.; Wagner, D. D. Blood, Volume: 102, Pages: 4229-35 (2003) [PubMed]
  • Mechanisms and implications of platelet discoid shape. Italiano, J. E., Jr.; Bergmeier, W.; Tiwari, S.; Falet, H.; Hartwig, J. H.; Hoffmeister, K. M.; Andre, P.; Wagner, D. D.; Shivdasani, R. A. Blood, Volume: 101, Pages: 4789-96 (2003) [PubMed]
  • Platelets in inflammation and thrombosis. Wagner, D. D.; Burger, P. C. Arterioscler Thromb Vasc Biol, Volume: 23, Pages: 2131-7 (2003) [PubMed]
  • Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain. Ni, H.; Papalia, J. M.; Degen, J. L.; Wagner, D. D. Blood, Volume: 102, Pages: 3609-14 (2003) [PubMed]
  • Platelet P-selectin facilitates atherosclerotic lesion development. Burger, P. C.; Wagner, D. D. Blood, Volume: 101, Pages: 2661-6 (2003) [PubMed]
  • Shear madness in TNF-alpha signaling. Wagner DD. Blood, Volume: 102, Pages: 2711-2712 (2003)
2002
  • Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPAR alpha. Sethi, S.; Ziouzenkova, O.; Ni, H.; Wagner, D. D.; Plutzky, J.; Mayadas, T. N. Blood, Volume: 100, Pages: 1340-6 (2002) [PubMed]
  • Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature. Gotte, M.; Joussen, A. M.; Klein, C.; Andre, P.; Wagner, D. D.; Hinkes, M. T.; Kirchhof, B.; Adamis, A. P.; Bernfield, M. Invest Ophthalmol Vis Sci, Volume: 43, Pages: 1135-41 (2002) [PubMed]
  • CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism. Andre, P.; Prasad, K. S.; Denis, C. V.; He, M.; Papalia, J. M.; Hynes, R. O.; Phillips, D. R.; Wagner, D. D. Nat Med, Volume: 8, Pages: 247-52 (2002) [PubMed]
2001
  • Interleukin 11 significantly increases plasma von Willebrand factor and factor VIII in wild type and von Willebrand disease mouse models. Denis, C. V.; Kwack, K.; Saffaripour, S.; Maganti, S.; Andre, P.; Schaub, R. G.; Wagner, D. D. Blood, Volume: 97, Pages: 465-72 (2001) [PubMed]
  • Localized reduction of atherosclerosis in von Willebrand factor-deficient mice. Methia, N.; Andre, P.; Denis, C. V.; Economopoulos, M.; Wagner, D. D.
    Blood, Volume: 98, Pages: 1424-8 (2001) [PubMed]
  • ApoE deficiency compromises the blood brain barrier especially after injury. Methia, N.; Andre, P.; Hafezi-Moghadam, A.; Economopoulos, M.; Thomas, K. L.; Wagner, D. D. Mol Med, Volume: 7, Pages: 810-5 (2001) [PubMed]
  • Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice. Denis, C. V.; Andre, P.; Saffaripour, S.; Wagner, D. D. Proc Natl Acad Sci U S A, Volume: 98, Pages: 4072-7 (2001) [PubMed]
  • Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice. Niederman, R.; Westernoff, T.; Lee, C.; Mark, L. L.; Kawashima, N.; Ullman-Culler, M.; Dewhirst, F. E.; Paster, B. J.; Wagner, D. D.; Mayadas, T.; Hynes, R. O.; Stashenko, P. J Clin Periodontol, Volume: 28, Pages: 569-75 (2001) [PubMed]
  • Increased thrombogenesis and embolus formation in mice lacking glycoprotein V. Ni, H.; Ramakrishnan, V.; Ruggeri, Z. M.; Papalia, J. M.; Phillips, D. R.; Wagner, D. D. Blood, Volume: 98, Pages: 368-73 (2001) [PubMed]
2000
  • Pro-coagulant state resulting from high levels of soluble P-selectin in blood. Andre, P.; Hartwell, D.; Hrachovinova, I.; Saffaripour, S.; Wagner, D. D.
    Proc Natl Acad Sci U S A, Volume: 97, Pages: 13835-40 (2000) [PubMed]
  • Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. Ni, H.; Denis, C. V.; Subbarao, S.; Degen, J. L.; Sato, T. N.; Hynes, R. O.; Wagner, D. D. J Clin Invest, Volume: 106, Pages: 385-92 (2000) [PubMed]
  • Prominent role of P-selectin in the development of advanced atherosclerosis in ApoE-deficient mice. Dong, Z. M.; Brown, A. A.; Wagner, D. D.
    Circulation, Volume: 101, Pages: 2290-5 (2000) [PubMed]
  • Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins. Andre, P.; Denis, C. V.; Ware, J.; Saffaripour, S.; Hynes, R. O.; Ruggeri, Z. M.; Wagner, D. D. Blood, Volume: 96, Pages: 3322-8 (2000) [PubMed]
  • P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. Frenette, P. S.; Denis, C. V.; Weiss, L.; Jurk, K.; Subbarao, S.; Kehrel, B.; Hartwig, J. H.; Vestweber, D.; Wagner, D. D. J Exp Med, Volume: 191, Pages: 1413-22 (2000) [PubMed]
1999
  • Insights from von Willebrand disease animal models. Denis, C. V.; Wagner, D. D. Cell Mol Life Sci, Volume: 56, Pages: 977-90 (1999) [PubMed]
  • Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions. Jia, G. Q.; Gonzalo, J. A.; Hidalgo, A.; Wagner, D.; Cybulsky, M.; Gutierrez-Ramos, J. C. Int Immunol, Volume: 11, Pages: 1-10 (1999) [PubMed]
  • New discoveries with mice mutant in endothelial and platelet selectins. Hartwell, D. W.; Wagner, D. D. Thromb Haemost, Volume: 82, Pages: 850-7 (1999) [PubMed]
  • Carboxypeptidase E does not mediate von Willebrand factor targeting to storage granules. Methia, N.; Denis, C. V.; Wagner, D. D. Eur J Cell Biol, Volume: 78, Pages: 884-91 (1999) [PubMed]
  • Donor MHC and adhesion molecules in transplant arteriosclerosis. Shi, C.; Feinberg, M. W.; Zhang, D.; Patel, A.; Sim, C. U.; Dong, Z. M.; Chapman, S. M.; Gutierrez-Ramos, J. C.; Wagner, D. D.; Sibinga, N. E.; Haber, E. J Clin Invest, Volume: 103, Pages: 469-74 (1999) [PubMed]
  • Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Enjyoji, K.; Sevigny, J.; Lin, Y.; Frenette, P. S.; Christie, P. D.; Esch, J. S., 2nd; Imai, M.; Edelberg, J. M.; Rayburn, H.; Lech, M.; Beeler, D. L.; Csizmadia, E.; Wagner, D. D.; Robson, S. C.; Rosenberg, R. D. Nat Med, Volume: 5, Pages: 1010-7 (1999) [PubMed]
  • P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury. Soriano, S. G.; Wang, Y. F.; Wagner, D. D.; Frenette, P. S.
    Brain Res, Volume: 835, Pages: 360-4 (1999) [PubMed]
  • Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment. Robinson, S. D.; Frenette, P. S.; Rayburn, H.; Cummiskey, M.; Ullman-Cullere, M.; Wagner, D. D.; Hynes, R. O. Proc Natl Acad Sci U S A, Volume: 96, Pages: 11452-7 (1999) [PubMed]
  • Structure, biology and genetics of von Willebrand factor. Ginsburg D and Wagner DD. In: Hematology: Basic Principles and Practices. 3rd Edition. Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE and McGlave P. (Eds.). New York: Churchill Livingstone (1999)
1998
  • Platelet-endothelial interactions in inflamed mesenteric venules. Frenette, P. S.; Moyna, C.; Hartwell, D. W.; Lowe, J. B.; Hynes, R. O.; Wagner, D. D.
    Blood, Volume: 91, Pages: 1318-24 (1998) [PubMed]
  • A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Denis, C.; Methia, N.; Frenette, P. S.; Rayburn, H.; Ullman-Cullere, M.; Hynes, R. O.; Wagner, D. D. Proc Natl Acad Sci U S A, Volume: 95, Pages: 9524-9 (1998) [PubMed]
  • Angiogenesis in P- and E-selectin-deficient mice. Hartwell, D. W.; Butterfield, C. E.; Frenette, P. S.; Kenyon, B. M.; Hynes, R. O.; Folkman, J.; Wagner, D. D. Microcirculation, Volume: 5, Pages: 173-8 (1998) [PubMed]
  • Leukocyte-endothelium adhesion molecules in atherosclerosis. Dong, Z. M.; Wagner, D. D. J Lab Clin Med, Volume: 132, Pages: 369-75 (1998) [PubMed]
  • P-Selectin and platelet clearance. Berger, G.; Hartwell, D. W.; Wagner, D. D. Blood, Volume: 92, Pages: 4446-52 (1998) [PubMed]
  • The transmembrane domain enhances granular targeting of P-selectin. Fleming, J. C.; Berger, G.; Guichard, J.; Cramer, E. M.; Wagner, D. D.
    Eur J Cell Biol, Volume: 75, Pages: 331-43 (1998) [PubMed]
  • P- and E-selectins are required for the leukocyte recruitment, but not the tissue swelling, associated with IgE- and mast cell-dependent inflammation in mouse skin. de Mora, F.; Williams, C. M.; Frenette, P. S.; Wagner, D. D.; Hynes, R. O.; Galli, S. J. Lab Invest, Volume: 78, Pages: 497-505 (1998) [PubMed]
  • The combined role of P- and E-selectins in atherosclerosis. Dong, Z. M.; Chapman, S. M.; Brown, A. A.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D. J Clin Invest, Volume: 102, Pages: 145-52 (1998) [PubMed]
  • Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow. Frenette, P. S.; Subbarao, S.; Mazo, I. B.; von Andrian, U. H.; Wagner, D. D. Proc Natl Acad Sci U S A, Volume: 95, Pages: 14423-8 (1998) [PubMed]
  • Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses. Hartwell, D. W.; Mayadas, T. N.; Berger, G.; Frenette, P. S.; Rayburn, H.; Hynes, R. O.; Wagner, D. D. J Cell Biol, Volume: 143, Pages: 1129-41 (1998) [PubMed]
  • Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. Mazo, I. B.; Gutierrez-Ramos, J. C.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.; von Andrian, U. H. J Exp Med, Volume: 188, Pages: 465-74 (1998) [PubMed]
  • Leukocytes fighting against obesity. Dong, Z. M.; Wagner, D. D. Mol Psychiatry, Volume: 3, Pages: 8-9 (1998) [PubMed]
  • E and P selectins are not required for resistance to severe murine lyme arthritis. Seiler, K. P.; Ma, Y.; Weis, J. H.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.; Weis, J. J. Infect Immun, Volume: 66, Pages: 4557-9 (1998) [PubMed]
  • Overlapping functions of E- and P-selectin in neutrophil recruitment during acute inflammation. Homeister, J. W.; Zhang, M.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.; Lowe, J. B.; Marks, R. M. Blood, Volume: 92, Pages: 2345-52 (1998) [PubMed]
1997
  • Genetic manipulation of vascular adhesion molecules in mice. Hynes, R. O.; Wagner, D. D. J Clin Invest, Volume: 100, Pages: S11-3 (1997) [PubMed]
  • A new class of obesity genes encodes leukocyte adhesion receptors. Dong, Z. M.; Gutierrez-Ramos, J. C.; Coxon, A.; Mayadas, T. N.; Wagner, D. D. Proc Natl Acad Sci U S A, Volume: 94, Pages: 7526-30 (1997) [PubMed]
  • Role of endothelial selectins in wound repair. Subramaniam, M.; Saffaripour, S.; Van De Water, L.; Frenette, P. S.; Mayadas, T. N.; Hynes, R. O.; Wagner, D. D. Am J Pathol, Volume: 150, Pages: 1701-9 (1997) [PubMed]
  • Insights into selectin function from knockout mice. Frenette, P. S.; Wagner, D. D. Thromb Haemost, Volume: 78, Pages: 60-4 (1997) [PubMed]
  • Generation and characterization of a novel adhesion function blocking monoclonal antibody recognizing both rat and mouse E-selectin. Walter, U. M.; Ayer, L. M.; Manning, A. M.; Frenette, P. S.; Wagner, D. D.; Hynes, R. O.; Wolitzky, B. A.; Issekutz, A. C. Hybridoma, Volume: 16, Pages: 355-61 (1997) [PubMed]
  • Characterization of a novel adhesion function blocking monoclonal antibody to rat/mouse P-selectin generated in the P-selectin-deficient mouse. Walter, U. M.; Ayer, L. M.; Wolitzky, B. A.; Wagner, D. D.; Hynes, R. O.; Manning, A. M.; Issekutz, A. C. Hybridoma, Volume: 16, Pages: 249-57 (1997) [PubMed]
  • Experimental murine acid aspiration injury is mediated by neutrophils and the alternative complement pathway. Weiser, M. R.; Pechet, T. T.; Williams, J. P.; Ma, M.; Frenette, P. S.; Moore, F. D.; Kobzik, L.; Hines, R. O.; Wagner, D. D.; Carroll, M. C.; Hechtman, H. B. J Appl Physiol, Volume: 83, Pages: 1090-5 (1997) [PubMed]
  • Absence of P-selectin delays fatty streak formation in mice. Johnson, R. C.; Chapman, S. M.; Dong, Z. M.; Ordovas, J. M.; Mayadas, T. N.; Herz, J.; Hynes, R. O.; Schaefer, E. J.; Wagner, D. D. J Clin Invest, Volume: 99, Pages: 1037-43 (1997) [PubMed]
1996
  • Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. Tang, T.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.; Mayadas, T. N. J Clin Invest, Volume: 97, Pages: 2485-90 (1996) [PubMed]
  • Defects in hemostasis in P-selectin-deficient mice. Subramaniam, M.; Frenette, P. S.; Saffaripour, S.; Johnson, R. C.; Hynes, R. O.; Wagner, D. D. Blood, Volume: 87, Pages: 1238-42 (1996) [PubMed]
  • Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. Pinsky, D. J.; Naka, Y.; Liao, H.; Oz, M. C.; Wagner, D. D.; Mayadas, T. N.; Johnson, R. C.; Hynes, R. O.; Heath, M.; Lawson, C. A.; Stern, D. M. J Clin Invest, Volume: 97, Pages: 493-500 (1996) [PubMed]
  • Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice. Mayadas, T. N.; Mendrick, D. L.; Brady, H. R.; Tang, T.; Papayianni, A.; Assmann, K. J.; Wagner, D. D.; Hynes, R. O.; Cotran, R. S. Kidney Int, Volume: 49, Pages: 1342-9 (1996) [PubMed]
  • Adhesion molecules--Part 1. Frenette, P. S.; Wagner, D. D. N Engl J Med, Volume: 334, Pages: 1526-9 (1996) [PubMed]
  • Genetic manipulation of vascular adhesion molecules in mice. Hynes, R. O.; Wagner, D. D. J Clin Invest, Volume: 98, Pages: 2193-5 (1996) [PubMed]
  • Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Frenette, P. S.; Mayadas, T. N.; Rayburn, H.; Hynes, R. O.; Wagner, D. D. Cell, Volume: 84, Pages: 563-74 (1996) [PubMed]
  • Adhesion molecules--Part II: Blood vessels and blood cells. Frenette, P. S.; Wagner, D. D. N Engl J Med, Volume: 335, Pages: 43-5 (1996) [PubMed]
  • Double knockout highlights value of endothelial selectins. Frenette, P. S.; Mayadas, T. N.; Rayburn, H.; Hynes, R. O.; Wagner, D. D. Immunol Today, Volume: 17, Pages: 205 (1996) [PubMed]
1995
  • Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin. Yamada, S.; Mayadas, T. N.; Yuan, F.; Wagner, D. D.; Hynes, R. O.; Melder, R. J.; Jain, R. K. Blood, Volume: 86, Pages: 3487-92 (1995) [PubMed]
  • Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Frenette, P. S.; Johnson, R. C.; Hynes, R. O.; Wagner, D. D. Proc Natl Acad Sci U S A, Volume: 92, Pages: 7450-4 (1995) [PubMed]
  • Blood cell dynamics in P-selectin-deficient mice. Johnson, R. C.; Mayadas, T. N.; Frenette, P. S.; Mebius, R. E.; Subramaniam, M.; Lacasce, A.; Hynes, R. O.; Wagner, D. D. Blood, Volume: 86, Pages: 1106-14 (1995) [PubMed]
  • P-selectin knockout: a mouse model for various human diseases. Wagner, D. D. Ciba Found Symp, Volume: 189, Pages: 2-10; discussion 10-16, 77-8 (1995) [PubMed]
  • P-selectin chases a butterfly. Wagner, D. D. J Clin Invest, Volume: 95, Pages: 1955-6 (1995) [PubMed]
  • Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice. Subramaniam, M.; Saffaripour, S.; Watson, S. R.; Mayadas, T. N.; Hynes, R. O.; Wagner, D. D. J Exp Med, Volume: 181, Pages: 2277-82 (1995) [PubMed]
  • Structure, biology and genetics of von Willebrand factor. Wagner DD and Ginsburg D. In: Hematology: Basic Principles and Practices. 2nd Edition. Benz EJ, Cohen HJ, Furie B, Hoffman R and Shattil SJ. (Eds.). New York: Churchill Livingstone., Pages: 1717-1725 (1995)
  • Gene targeting of adhesion molecules in the vasculature. Wagner DD and Hynes RO. In: Series: Molecular genetics and gene therapy of cardiovascular diseases. Mockrin SC (Ed.) New York: Marcel Dekker., Pages: 403-405 (1995)
  • P-selectin-deficient mice: A model to study inflammation and metastasis. In: Series: Topics in Molecular Medicine Vol 1. Siess W, Lorenz R and Weber PC. (Eds.). New York: Raven Press., Pages: 105-116 (1995)
1994
  • von Willebrand factor proteolytic processing and multimerization precede the formation of Weibel-Palade bodies Vischer, U. M.; Wagner, D. D. Blood, Volume: 83, Pages: 3536-44 (1994) [PubMed]
1993
  • P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancer. Stone, J. P.; Wagner, D. D. J Clin Invest, Volume: 92, Pages: 804-13 (1993) [PubMed]
  • Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Mayadas, T. N.; Johnson, R. C.; Rayburn, H.; Hynes, R. O.; Wagner, D. D. Cell, Volume: 74, Pages: 541-54 (1993) [PubMed]
  • Divergent fates of P- and E-selectins after their expression on the plasma membrane. Subramaniam, M.; Koedam, J. A.; Wagner, D. D. Mol Biol Cell, Volume: 4, Pages: 791-801 (1993) [PubMed]
  • von Willebrand factor storage requires intact prosequence cleavage site. Journet, A. M.; Saffaripour, S.; Cramer, E. M.; Tenza, D.; Wagner, D. D.
    Eur J Cell Biol, Volume: 60, Pages: 31-41 (1993) [PubMed]
  • CD63 is a component of Weibel-Palade bodies of human endothelial cells. Vischer, U. M.; Wagner, D. D. Blood, Volume: 82, Pages: 1184-91 (1993) [PubMed]
  • The Weibel-Palade body: the storage granule for von Willebrand factor and P-selectin. Wagner, D. D. Thromb Haemost, Volume: 70, Pages: 105-10 (1993) [PubMed]
  • Requirement for both D domains of the propolypeptide in von Willebrand factor multimerization and storage. Journet, A. M.; Saffaripour, S.; Wagner, D. D. Thromb Haemost, Volume: 70, Pages: 1053-7 (1993) [PubMed]
1992
  • P-selectin, a granule membrane protein of platelets and endothelial cells, follows the regulated secretory pathway in AtT-20 cells. Koedam, J. A.; Cramer, E. M.; Briend, E.; Furie, B.; Furie, B. C.; Wagner, D. D. J Cell Biol, Volume: 116, Pages: 617-25 (1992) [PubMed]
  • Vicinal cysteines in the prosequence play a role in von Willebrand factor multimer assembly. Mayadas, T. N.; Wagner, D. D. Proc Natl Acad Sci U S A, Volume: 89, Pages: 3531-5 (1992) [PubMed]
  • A 130-kDa protein on endothelial cells binds to amino acids 15-42 of the B beta chain of fibrinogen. Erban, J. K.; Wagner, D. D. J Biol Chem, Volume: 267, Pages: 2451-8 (1992) [PubMed]
  • P-selectin and E-selectin. Distinct but overlapping leukocyte ligand specificities. Larsen, G. R.; Sako, D.; Ahern, T. J.; Shaffer, M.; Erban, J.; Sajer, S. A.; Gibson, R. M.; Wagner, D. D.; Furie, B. C.; Furie, B. J Biol Chem, Volume: 267, Pages: 11104-10 (1992) [PubMed]
1991
  • Induction of specific storage organelles by von Willebrand factor propolypeptide. Wagner, D. D.; Saffaripour, S.; Bonfanti, R.; Sadler, J. E.; Cramer, E. M.; Chapman, B.; Mayadas, T. N. Cell, Volume: 64, Pages: 403-13 (1991) [PubMed]
  • PADGEM, a leukocyte receptor on activated platelets. Biology and application to in vivo medical diagnostics. Furie, B.; Celi, A.; Palabrica, T. M.; Larsen, E.; Wagner, D. D.; Furie, B. C. Curr Stud Hematol Blood Transfus, Pages: 32-6 (1991) [PubMed]
  • von Willebrand factor and the endothelium. Wagner, D. D.; Bonfanti, R. Mayo Clin Proc, Volume: 66, Pages: 621-7 (1991) [PubMed]
  • von Willebrand factor biosynthesis and processing. Mayadas, T. N.; Wagner, D. D. Ann N Y Acad Sci, Volume: 614, Pages: 153-66 (1991) [PubMed]
  • PADGEM a Leukocyte Receptor on Activated Platelets: Biology and application to in vivo medical diagnostics. Furie B, Celi A, Palabrica TM, Larsen E, Wagner DD and Furie, BC. In: Biotechnology of Plasma Proteins: Haemostasis, Thrombosis and Iron Proteins. Albertini A, L’Enfant CL, Mannucci PM, and Sixma JJ. (Eds). Basel: Karger., Pages: 32-36. (1991)
  • Selectins: A family of adhesion receptors. Letter to the Editor. Bevilacqua E, Butcher E, Furie B, Furie B, Gallatin M, Gimbrone M, Harlan J, Kishimoto K, Lasky L, McEver R, Paulson J, Rosen S, Seed B, Siegelman M, Springer T, Stoolman L, Tedder T, Varki A, Wagner D, Weissman I and Zimmerman G. Cell., Volume: 67., Pages: 233. (1991)
  • Structure and biology of von Willebrand factor. Wagner DD. In: Hematology: Basic Principles and Practices. Benz EJ, Cohen HJ, Furie B, Hoffman R and Shattil SJ. (Eds.). New York: Churchill Livingstone., Pages: 1354-1358. (1991)
1990
  • Human endothelial cells synthesize, process, and secrete fibronectin molecules bearing an alternatively spliced type III homology (ED1). Peters, J. H.; Sporn, L. A.; Ginsberg, M. H.; Wagner, D. D. Blood, Volume: 75, Pages: 1801-8 (1990) [PubMed]
  • Cell biology of von Willebrand factor. Wagner, D. D. Annu Rev Cell Biol, Volume: 6, Pages: 217-46 (1990) [PubMed]
  • PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15). Larsen, E.; Palabrica, T.; Sajer, S.; Gilbert, G. E.; Wagner, D. D.; Furie, B. C.; Furie, B. Cell, Volume: 63, Pages: 467-74 (1990) [PubMed]
1989
  • In vitro multimerization of von Willebrand factor is triggered by low pH. Importance of the propolypeptide and free sulfhydryls. Mayadas, T. N.; Wagner, D. D. J Biol Chem, Volume: 264, Pages: 13497-503 (1989) [PubMed]
  • PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes Larsen, E.; Celi, A.; Gilbert, G. E.; Furie, B. C.; Erban, J. K.; Bonfanti, R.; Wagner, D. D.; Furie, B. Cell, Volume: 59, Pages: 305-12 (1989) [PubMed]
  • von Willebrand factor biosynthesis and partitioning between constitutive and regulated pathways of secretion after thrombin stimulation. Mayadas, T.; Wagner, D. D.; Simpson, P. J. Blood, Volume: 73, Pages: 706-11 (1989) [PubMed]
  • Molecular and cellular biology of von Willebrand factor. Handin, R. I.; Wagner, D. D. Prog Hemost Thromb, Volume: 9, Pages: 233-59 (1989) [PubMed]
  • PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells. Bonfanti, R.; Furie, B. C.; Furie, B.; Wagner, D. D. Blood, Volume: 73, Pages: 1109-12 (1989) [PubMed]
  • Differing polarity of the constitutive and regulated secretory pathways for von Willebrand factor in endothelial cells. Sporn, L. A.; Marder, V. J.; Wagner, D. D. J Cell Biol, Volume: 108, Pages: 1283-9 (1989) [PubMed]
  • Plasma selenium-dependent glutathione peroxidase. Cell of origin and secretion. Avissar, N.; Whitin, J. C.; Allen, P. Z.; Wagner, D. D.; Liegey, P.; Cohen, H. J. J Biol Chem, Volume: 264, Pages: 15850-5 (1989) [PubMed]
  • Mediation of fibrin-induced release of von Willebrand factor from cultured endothelial cells by the fibrin beta chain. Ribes, J. A.; Ni, F.; Wagner, D. D.; Francis, C. W. J Clin Invest, Volume: 84, Pages: 435-42 (1989) [PubMed]
  • Temperature-sensitive steps in the secretory pathway for von Willebrand factor in endothelial cells. Roarke, M. C.; Wagner, D. D.; Marder, V. J.; Sporn, L. A. Eur J Cell Biol, Volume: 48, Pages: 337-43 (1989) [PubMed]
  • Storage and secretion of von Willebrand factor. Wagner DD. In: Role of Factor VIII and von Willebrand Factor. Zimmerman TS and Ruggeri ZM. (Eds.). New York: Marcel Dekker., Pages: 161-180. (1989)
1987
  • Topology and order of formation of interchain disulfide bonds in von Willebrand factor. Wagner, D. D.; Lawrence, S. O.; Ohlsson-Wilhelm, B. M.; Fay, P. J.; Marder, V. J. Blood, Volume: 69, Pages: 27-32 (1987) [PubMed]
  • Divergent fates of von Willebrand factor and its propolypeptide (von Willebrand antigen II) after secretion from endothelial cells. Wagner, D. D.; Fay, P. J.; Sporn, L. A.; Sinha, S.; Lawrence, S. O.; Marder, V. J. Proc Natl Acad Sci U S A, Volume: 84, Pages: 1955-9 (1987) [PubMed]
  • Intact microtubules are necessary for complete processing, storage and regulated secretion of von Willebrand factor by endothelial cells. Sinha, S.; Wagner, D. D. Eur J Cell Biol, Volume: 43, Pages: 377-83 (1987) [PubMed]
  • von Willebrand factor released from Weibel-Palade bodies binds more avidly to extracellular matrix than that secreted constitutively. Sporn, L. A.; Marder, V. J.; Wagner, D. D. Blood, Volume: 69, Pages: 1531-4 (1987) [PubMed]
  • Fibrin induces release of von Willebrand factor from endothelial cells. Ribes, J. A.; Francis, C. W.; Wagner, D. D. J Clin Invest, Volume: 79, Pages: 117-23 (1987) [PubMed]
1986
  • Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II. Fay, P. J.; Kawai, Y.; Wagner, D. D.; Ginsburg, D.; Bonthron, D.; Ohlsson-Wilhelm, B. M.; Chavin, S. I.; Abraham, G. N.; Handin, R. I.; Orkin, S. H.; et al., Science, Volume: 232, Pages: 995-8 (1986) [PubMed]
  • Inducible secretion of large, biologically potent von Willebrand factor multimers. Sporn, L. A.; Marder, V. J.; Wagner, D. D. Cell, Volume: 46, Pages: 185-90 (1986) [PubMed]
  • Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor. Wagner, D. D.; Mayadas, T.; Marder, V. J. J Cell Biol, Volume: 102, Pages: 1320-4 (1986) [PubMed]
1985
  • Biosynthesis of von Willebrand protein by human megakaryocytes. Sporn, L. A.; Chavin, S. I.; Marder, V. J.; Wagner, D. D. J Clin Invest, Volume: 76, Pages: 1102-6 (1985) [PubMed]
  • Inhibition of disulfide bonding of von Willebrand protein by monensin results in small, functionally defective multimers. Wagner, D. D.; Mayadas, T.; Urban-Pickering, M.; Lewis, B. H.; Marder, V. J. J Cell Biol, Volume: 101, Pages: 112-20 (1985) [PubMed]
1984
  • Von Willebrand protein binds to extracellular matrices independently of collagen. Wagner, D. D.; Urban-Pickering, M.; Marder, V. J. Proc Natl Acad Sci U S A, Volume: 81, Pages: 471-5 (1984) [PubMed]
  • Irradiation induces release of von Willebrand protein from endothelial cells in culture. Sporn, L. A.; Rubin, P.; Marder, V. J.; Wagner, D. D. Blood, Volume: 64, Pages: 567-70 (1984) [PubMed]
  • Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization. Wagner, D. D.; Marder, V. J. J Cell Biol, Volume: 99, Pages: 2123-30 (1984) [PubMed]
1983
  • Biosynthesis of von Willebrand protein by human endothelial cells. Identification of a large precursor polypeptide chain. Wagner, D. D.; Marder, V. J. J Biol Chem, Volume: 258, Pages: 2065-7 (1983) [PubMed]
1982
  • Relationships between microfilaments, cell-substratum adhesion, and fibronectin. Hynes, R. O.; Destree, A. T.; Wagner, D. D. Cold Spring Harb Symp Quant Biol, Volume: 46 Pt 2, Pages: 659-70 (1982) [PubMed]
  • Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells. Wagner, D. D.; Olmsted, J. B.; Marder, V. J. J Cell Biol, Volume: 95, Pages: 355-60 (1982) [PubMed]
  • Fibronectin-coated beads are endocytosed by cells and align with microfilament bundles. Wagner, D. D.; Hynes, R. O. Exp Cell Res, Volume: 140, Pages: 373-81 (1982) [PubMed]
  • Fibronectin dependent endocytosis by macrophage like (P388D1) and fibroblastic (NIL 8) cells. Van De Water L III, Wagner DD, Crenshaw EB III and Hynes RO. In: Cellular Recognition. Glaser L, Frazier W and Gottlieb D (Eds.). New York: Alan R. Liss., Pages: 869-878 (1982)
1981
  • Similarities and differences between the fibronectins of normal and transformed hamster cells. Wagner, D. D.; Ivatt, R.; Destree, A. T.; Hynes, R. O. J Biol Chem, Volume: 256, Pages: 11708-15 (1981) [PubMed]
1980
  • Topological arrangement of the major structural features of fibronectin. Wagner, D. D.; Hynes, R. O. J Biol Chem, Volume: 255, Pages: 4304-12 (1980) [PubMed]
1979
  • Cell surface fibronectin and oncogenic transformation. Hynes, R. O.; Destree, A. T.; Perkins, M. E.; Wagner, D. D. J Supramol Struct, Volume: 11, Pages: 95-104 (1979) [PubMed]
  • Domain structure of fibronectin and its relation to function. Disulfides and sulfhydryl groups. Wagner, D. D.; Hynes, R. O. J Biol Chem, Volume: 254, Pages: 6746-54 (1979) [PubMed]
1978
  • A large glycoprotein lost from the surfaces of transformed cells. Hynes, R. O.; Ali, I. U.; Destree, A. T.; Mautner, V.; Perkins, M. E.; Senger, D. R.; Wagner, D. D.; Smith, K. K. Ann N Y Acad Sci, Volume: 312, Pages: 317-42 (1978) [PubMed]​